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TranscriptomicsSystems approach identifies HIPK2 as a critical regulator of kidney tubulointerstitial fibrosis
We used an integrated computational/experimental systems biology approach to identify upstream protein kinases that regulate gene expression changes in kidneys of HIV-1 transgenic mice (Tg26), which have significant tubulo-interstitial fibrosis (TIF) and glomerulosclerosis (GS). We identified the ho...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-35226 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of striatal tissue of wild type and Ezh1/Ezh2 dKO mice at 6 weeks, 3 months, and 6 months
Normal brain function critically depends on the interaction between highly specialized neurons that operate within anatomically and functionally distinct brain regions. The fidelity of neuronal specification is contingent upon the robustness of the transcriptional program that supports the neuron ty...
ORGANISM(S): Mus musculus 
2016-07-29 | E-GEOD-84243 | biostudies-arrayexpress
GenomicsHomo sapiens
Histone H3.3 and its proteolytically processed form drive a cellular senescence program
PRJNA241413 | ENA
GenomicsHomo sapiens
A Curcumin-Based CBP HAT Inhibitor Modulates the Transcription Functions of Tumor Suppressor p53
PRJNA354786 | ENA
GenomicsHabenular Tcf7l2 links nicotine addiction to diabetes
Habenular Tcf7l2 links nicotine addiction to diabetes
PRJNA564583 | ENA
GenomicsGenome-wide maps of chromatin state in medium spiny neurons in the striatum of adult mice
Normal brain function critically depends on the interaction between highly specialized neurons that operate within anatomically and functionally distinct brain regions. The fidelity of neuronal specification is contingent upon the robustness of the transcriptional program that supports the neuron ty...
ORGANISM(S): Mus musculus 
2016-07-29 | E-GEOD-84244 | biostudies-arrayexpress
TranscriptomicsRegulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling
Illumina Beadchip array analyses of mouse embryonic stem cell gene expression profiles in the presence of or upon knockdown of Aurka. An ES complementation 'rescue' system was employed to measure the effects of knockdown (minus Dox). Aurka was rescued to wildtype levels in the presence of Dox (plus ...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-23541 | biostudies-arrayexpress
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