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UnknownADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium.
Very low-density lipoprotein receptor (VLDLR) is a multifunctional transmembrane protein. Beyond the function of the full-length VLDLR in lipid transport, the soluble ectodomain of VLDLR (sVLDLR) confers anti-inflammatory and antiangiogenic roles in ocular tissues through inhibition of canonical Wnt...
S-EPMC8487060 | biostudies-literature
UnknownIdentification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65.
RPE65 is a membrane-associated protein abundantly expressed in the retinal pigment epithelium, which converts all-trans-retinyl ester to 11-cis-retinol, a key step in the retinoid visual cycle. Although three cysteine residues (Cys-231, Cys-329, and Cys-330) were identified to be palmitylated in RPE...
S-EPMC2631947 | biostudies-literature
UnknownA novel role of LRP5 in tubulointerstitial fibrosis through activating TGF-β/Smad signaling.
Previous studies by us and others demonstrated that activation of Wnt/β-catenin signaling plays a pathogenic role in chronic kidney diseases (CKD). Wnt co-receptor LRP5 variants are reported to associate with autosomal dominant polycystic kidney disease; but their exact roles in this disease and ren...
S-EPMC7188863 | biostudies-literature
UnknownA Protective Effect of PPARα in Endothelial Progenitor Cells Through Regulating Metabolism.
Deficiency of endothelial progenitor cells, including endothelial colony-forming cells (ECFCs) and circulating angiogenic cells (CACs), plays an important role in retinal vascular degeneration in diabetic retinopathy (DR). Fenofibrate, an agonist of peroxisome proliferator-activated receptor α (PPAR...
S-EPMC6804623 | biostudies-literature
UnknownIdentification of key residues determining isomerohydrolase activity of human RPE65.
RPE65 is the retinoid isomerohydrolase that converts all-trans-retinyl ester to 11-cis-retinol, a key reaction in the retinoid visual cycle. We have previously reported that cone-dominant chicken RPE65 (cRPE65) shares 90% sequence identity with human RPE65 (hRPE65) but exhibits substantially higher ...
S-EPMC4175317 | biostudies-literature
UnknownPPARα is essential for retinal lipid metabolism and neuronal survival.

Background

Peroxisome proliferator activated receptor-alpha (PPARα) is a ubiquitously expressed nuclear receptor. The role of endogenous PPARα in retinal neuronal homeostasis is unknown. Retinal photoreceptors are the highest energy-consuming cells in the body, requiring abundant energy subs...
S-EPMC5706156 | biostudies-literature
UnknownPigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway.
Pigment epithelium-derived factor (PEDF) expression is downregulated in the kidneys of diabetic rats, and delivery of PEDF suppressed renal fibrotic factors in these animals. PEDF has multiple functions including anti-angiogenic, anti-inflammatory and antifibrotic activities. Since the mechanism und...
S-EPMC5313326 | biostudies-literature
UnknownNanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization.

Objective

The deficiency of very low-density lipoprotein receptor resulted in Wnt signaling activation and neovascularization in the retina. The present study sought to determine whether the very low-density lipoprotein receptor extracellular domain (VLN) is responsible for the inhibition of...
S-EPMC4376607 | biostudies-literature
UnknownAnti-angiogenic effect of a humanized antibody blocking the Wnt/β-catenin signaling pathway.

Purpose

Our previous study demonstrated that Mab2F1, a murine monoclonal antibody blocking the Wnt/β-catenin signaling pathway, has beneficial effects on experimental diabetic retinopathy and choroidal neovascularization (NV). The aforementioned antibody has been humanized. This study evalua...
S-EPMC6636822 | biostudies-literature
UnknownPeroxisome proliferator-activated receptor α protects capillary pericytes in the retina.
Pericyte degeneration is an early event in diabetic retinopathy and plays an important role in progression of diabetic retinopathy. Clinical studies have shown that fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, has robust therapeutic effects on diabetic retinopathy in ...
S-EPMC4188867 | biostudies-literature
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