To identify the late endosome LE/MVB proteome related to the endosomal microautophagy eMI activity we purified subcellular organelles including cytosol, late endosomes (LE/MVBs) and lysosomes (CMA+) from the rat liver and performed co-Ip experiment with antibodies directed against the major cellular...
This phase I/II neoadjuvant trial determined maximally-tolerated doses (MTD), dose-limiting toxicities (DLT), response-to-therapy, and explored the role of new response biomarkers. The combination regimens were delivered with acceptable toxicity, good clinical response, inducing changes in tumor RNA...
To identify the subproteome degraded by endosomal microautophagy (eMI) in a Bag6-dependent manner, we compared the proteome of late endosomal compartments LE/MVBs isolated from control(wild type) and Bag6(-) cells using SILAC labeling and quantitative proteomics.
ISA Brown Warren medium heavy layer hens were divergently selected for 25 generations on their primary immune response. Two selection chicken lines were established: chickens with a high natural antibody response (H) and chicken with a low natural antibody response (L). Besides a control line of ran...
This a model from the article:
Quantifying robustness of biochemical network models.
Ma L, Iglesias PA.
BMC Bioinformatics.2002 Dec 13;3:38.
12482327,
Abstract:
BACKGROUND: Robustness of mathematical models of biochemical networks is impo...
Based on activities of daily living assessments at admission and followed by a 3-month recovery, ischemic stroke participants were categorized into the groups involving the recovery of little effective (LE) and obvious effective (OE). Differentially expressed proteins (DEPs) derived from proteomic t...
