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Skeletal muscle mass and function decline more precipitously after the age 75 y. To provide insights into biologically relevant mechanisms for preserving muscle mass and physical function in advanced age, a battery of physical function tests, muscle cross-sectional area by MRI and a vastus lateralis...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
Zebrafish (n=420; 70/treatment) were weighed and placed in 8L aerated tanks,
served with flow-through soft-water at 25ml/min. A combination of Mariotte bottles
were used to dose tanks with Cu (concentrated Cu solution made from CuSO4 dissolved
in 0.05% HNO3), Na (concentrated NaCl solution)...
ORGANISM(S): Danio rerio 
Background. Mutations in ATP1A2 gene encoding the Na,K-ATPase α2 isoform is associated with familial hemiplegic migraine type 2 (FHM2). Migraine with aura is a known risk factor for heart disease. The Na,K-ATPase is important for cardiac function but its role for heart disease remains unknown. We hy...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-05-20 | PXD028952 | Pride
The experiment is aiming to analyze the effect of overexpression of the Arabidopsis At1g06160 AP2/ERF-domain transcription factor on gene expression and the involvement of the At1g06160-regulated genes in the jasmonic acid or jasmonic acid/ethylene signal transduction pathways. The experiment was pe...
ORGANISM(S): Arabidopsis thaliana 
Sulfamethoxazole (SMX) is associated with idiosyncratic drug induced liver injury (DILI), which remains difficult to predict. SMX is primarily metabolized by the N-acetyltransferases NAT1 and NAT2 to form N4-acetyl sulfamethoxazole (NA-SMX) and by cytochrome P450-mediated oxidation to form SMX-hydro...
ORGANISM(S): Homo sapiens (Human) 
2025-12-06 | PXD066786 | Pride
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