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MetabolomicsSingle-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the 'best' indicator of metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular typing system to predict colorectal cancer metastasis potent...

2023-08-21 | MTBLS5028 | MetaboLights
TranscriptomicsGlobal analysis of metastasis-associated gene expression in the primary cultures from clinical specimens of ccRCC
Metastatic clear cell renal cell carcinoma (ccRCC) has a poor prognosis and unpredictable course and there are no molecular markers that reliably predict ccRCC metastasis. In this study, specimens from 84 patients with ccRCC were directly cultured in vitro. The primary cultures from 38 of 94 specime...
ORGANISM(S): Homo sapiens 
2008-08-27 | E-GEOD-11072 | biostudies-arrayexpress
TranscriptomicsExpression profiles from a variety of resting and activated human immune cells
Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. In order to identify such patterns, we set out to broadly profile gene expression in a variety of immune cells. We isolated twelve different types of human leukocytes from peripheral blood an...
ORGANISM(S): Homo sapiens 
2010-07-13 | E-GEOD-22886 | biostudies-arrayexpress
Transcriptomics2009 pandemic H1N1 virus causes disease and upregulation of genes related to inflammatory and immune response, cell death, and lipid metabolism in pigs
This study used virological, histological, and global gene expression data to compare the virulence of two 2009 pH1N1 isolates from human (A/California/04/2009) and swine (A/swine/Alberta/25/2009) to that of a 1918-like classical swine influenza virus (A/swine/Iowa/1930) in a pig model of infection....
ORGANISM(S): Sus scrofa 
2012-02-13 | E-GEOD-35738 | biostudies-arrayexpress
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