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MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
UnknownIGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways.
Not available
S-EPMC9875405 | biostudies-literature
UnknownMolecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide.
Not available
S-EPMC10202051 | biostudies-literature
ProteomicsHaliotis discus hannai cerebral ganglion LC-MS
The circadian rhythm is the most general and important rhythm in biological organisms. In this study, continuous 24 h video recordings showed that the cumulative movement distance and duration of the abalone, Haliotis discus hannai reached their maximum values between 20:00–00:00, but both were sign...
ORGANISM(S): Haliotis discus hannai 
2022-08-12 | PXD029815 | Pride
Movement behaviour Haliotis discus hannai Cholinergic system 
ProteomicsChanges in the plasma proteome of Manduca sexta larvae in relation to the transcriptome variations after an immune challenge: evidence for high molecular weight immune complex formation
Manduca sexta is a lepidopteran model widely used to study insect physiological processes including innate immunity. In this study, we explored the proteomes of cell-free hemolymph from larvae injected with a sterile buffer (C for control) or a mixture of bacteria (I for induced). Of the 654 protein...
ORGANISM(S): Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 
2016-02-01 | PXD003267 | Pride
Protein processing Hemolymph proteins Tobacco hornworm Phenoloxidase activation Insect immunity Spectral counting Lc-ms/ms 
MetabolomicsArginine depletion-induced autophagy and metabolic dysregulation are involved in the disease severity of hand, foot, and mouth disease
Amino acid metabolism provides significant insight into the development and prevention of many viral diseases. Therefore, the present study aimed to compare the amino acid profiles of hand, foot, and mouth disease (HFMD) patients with those of healthy individuals and to further reveal the molecular ...
2024-10-25 | MTBLS11341 | MetaboLights
ProteomicsSUMOylation fine tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis
Reversible HEY1 SUMOylation is a molecular mechanism that coordinates endothelial angiogenic signaling and angiogenesis, both in physiological and pathological milieus, by fine tuning the transcriptional activity of HEY1. Specifically, S UMOylation facilitates the formation of the HEY1 transcription...
ORGANISM(S): Homo Sapiens 
2023-08-18 | PXD044611 |
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