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Analysis of HSCs from control and c-myc N-myc deficient long-term hematopoietic stem cells. HSCs lacking both c-myc and N-myc display increased apoptosis rates. Data provide insight into the molecular changes occuring upon complete loss of Myc activity, clarifying the resulting apoptotic mechanism a...
ORGANISM(S): Mus musculus 
Goal was to investigate the transcriptional effect of Hepatitis C Virus (HCV) infection upon hepatic gene expression in a primary tissue system. Cultured Primary human hepatocytes were infected with HCV (genotype 2a-JFH1) and maintained through a timecourse in parallel with matched controls of uninf...
ORGANISM(S): Homo sapiens 
Individuals with Alzheimer Disease with psychotic symptoms (AD+P) experience more rapid cognitive and functional decline, and have reduced indices of synaptic integrity, relative to those without psychosis (AD-P). We hypothesized the postsynaptic density (PSD) proteome is altered in AD+P relative to...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD042026 | Pride
This model is from the article: Genetic and metabolic determinants of nutritional phenotype in an insect-bacterial symbiosis. MacDonald SJ, Thomas GH, Douglas AE. Mol Ecol. 2011 May;20(10):2073-84. 21392141 , Abstract: ...
2005-01-01 | MODEL1012300000 | BioModels
Individuals with Alzheimer Disease who develop psychotic symptoms (AD+P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P). We sought to determine whether the postsynaptic density (PSD) proteome is altered in AD+P relati...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD042025 | Pride
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