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TranscriptomicsHistone deacetylase inhibitors antagonize distinct pathways to suppress tumorigenesis of embryonal rhabdomyosarcoma.
Embryonal rhabdomyosarcoma (ERMS) is the most common soft tissue cancer in children and is characterized by myogenic differentiation arrest. The prognosis of patients with relapsed or metastatic disease remains poor. ERMS genomes show few recurrent mutations, suggesting that other molecular mechani...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-74970 | biostudies-arrayexpress
TranscriptomicsRepeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects in maternal and fetal tissues
Chlorpyrifos oxon (CPO), the toxic metabolite of the organophosphorus (OP) insecticide chlorpyrifos, causes developmental neurotoxicity in humans and rodents. CPO is hydrolyzed by paraoxonase-1 (PON1), with protection determined by PON1 levels and the human Q192R polymorphism. To examine how the Q19...
ORGANISM(S): Mus musculus 
2014-08-04 | E-GEOD-58103 | biostudies-arrayexpress
ProteomicsMouse Skeletal Muscle Sarcopenia
Our study aimed to characterize sarcopenia in C57BL/6J mice using a clinically relevant definition and age range and investigate the underlying mechanisms leading to sarcopenia. Aged male C57BL/6J mice (23-32 months) were classified as non-sarcopenic (no deficit), probable sarcopenic (1 deficit), an...
ORGANISM(S): Mus Musculus 
2024-08-19 | PXD048723 | panorama
UnknownEffects of body size on estimation of mammalian area requirements.
Not available
S-EPMC7496598 | biostudies-literature
UnknownAntiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial.
Not available
S-EPMC3361667 | biostudies-literature
UnknownMeta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
Not available
S-EPMC3896259 | biostudies-literature
UnknownMultiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans.
Not available
S-EPMC4572072 | biostudies-literature
UnknownGene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.
Not available
S-EPMC5379914 | biostudies-literature
UnknownAntibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab.
Not available
S-EPMC8927425 | biostudies-literature
UnknownEffect of Thromboprophylaxis on Clinical Outcomes After COVID-19 Hospitalization.
Not available
S-EPMC10064277 | biostudies-literature
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