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TranscriptomicsMthfd1 is a modifier of intestinal carcinogenesis
The metabolic pathways that underlie the association between folate deficiency and increased risk for colorectal cancer (CRC) remain unclear. We have studied the effect of C1THF synthase (encoded by the Mthfd1 gene) and dietary folate and choline on intestinal tumor development in Apcmin/+ mice and ...
ORGANISM(S): Mus musculus 
2010-03-20 | E-GEOD-15419 | biostudies-arrayexpress
TranscriptomicsGene expression data of cSHMT mutant, heterozygous, and wild-type mouse colons
Folate-mediated one-carbon metabolism is required for purine, thymidylate, and S-adenosylmethionine synthesis. Impairments in folate metabolism diminish cellular methylation potential and genome stability. Cytoplasmic serine hydroxymethyl transferase (cSHMT) regulates partitioning between thymidylat...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-14645 | biostudies-arrayexpress
GenomicsHigh-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism
Dietary folate is a major source of methyl groups required for DNA methylation, an epigenetic modification that is actively maintained and remodelled during spermatogenesis. While high dose folic acid supplementation (up to ten times the daily recommended dose) has been shown to improve sperm parame...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-72606 | biostudies-arrayexpress
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