Sort   by:  
 Page size 
MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
MetabolomicsLimited survival and impaired hepatic fasting metabolism of glucose, amino acids and lipids in mice with constitutive Rag GTPase signaling
The mechanistic target of rapamycin complex 1 (mTORC1) integrates cellular nutrient signaling and hormonal cues to control metabolism. We have previously shown that constitutive nutrient signaling to mTORC1 by means of genetic activation of RagA (RagAGTP) in mice resulted in a fatal energetic crisis...
2021-05-11 | MTBLS2397 | MetaboLights
UnknownRole of core-shell energetics on anti-Mackay, chiral stacking in AgCu nanoalloys and thermally induced transition to chiral stacking.
Not available
S-EPMC7039915 | biostudies-literature
UnknownThe relationship of renal function to segmental vascular stiffness, ankle-brachial index, and peripheral artery disease.
Not available
S-EPMC8031290 | biostudies-literature
UnknownBuilding a model for predicting metabolic syndrome using artificial intelligence based on an investigation of whole-genome sequencing.
Not available
S-EPMC9052619 | biostudies-literature
UnknownBio-Plex immunoassay measuring the quantity of lysosomal N-acetylgalactosamine-6-sulfatase protein in dried blood spots for the screening of mucopolysaccharidosis IVA in newborn: a pilot study.
Not available
S-EPMC5734244 | biostudies-literature
TranscriptomicsGDNF-RET signaling as a target in aromatase inhibitor resistant breast cancers
Understanding the complex molecular mechanisms underlying resistance to endocrine therapy is a major challenge in the treatment of estrogen receptor-positive (ER+) breast cancers. We have previously demonstrated that glial cell line-derived neurotrophic factor (GDNF) signaling via the receptor tyros...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MEXP-3662 | biostudies-arrayexpress
UnknownPsychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study.
Not available
S-EPMC8032933 | biostudies-literature
UnknownPhomaketide A Inhibits Lymphangiogenesis in Human Lymphatic Endothelial Cells.
Not available
S-EPMC6520718 | biostudies-literature
Sort   by:  
 Page size