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TranscriptomicsRNA-seq from control and macroH2A1-depleted IMR90 primary human lung fibroblasts
The histone variant macroH2A1 and the poly(ADP-ribose) polymerase PARP-1 both regulate gene transcription by modulating chromatin structure and function. Of the two macroH2A1 splice variants, macroH2A1.1 and macroH2A1.2, the former is often suppressed in cancer and has the unique ability to interact...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-54846 | biostudies-arrayexpress
ProteomicsA map of post-translational modifications of macroH2A1 splicing variants and their interactome
The aim was to characterize PTM of macroH2A1.1 and macro H2A1.2 by LC-MS/MS to facilitate the understanding of their distinct biological functions in health and disease. Next, the interactome of macroH2A1 isoforms was investigated to elucidate whether the two variants could differentially orchestrat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022968 | Pride
Histone Dna repair Human Lc-ms/ms 
GenomicsLoss of macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization
Loss of macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization
PRJNA1072668 | ENA
GenomicsEpigenetic control of Topoisomerase 1 by macroH2A1.1
Epigenetic control of Topoisomerase 1 by macroH2A1.1
PRJNA1143591 | ENA
GenomicsEpigenetic control of Topoisomerase 1 by macroH2A1.1
Epigenetic control of Topoisomerase 1 by macroH2A1.1
PRJNA1143592 | ENA
UnknownLoss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization.
Not available
S-EPMC12551714 | biostudies-literature
TranscriptomicsLoss of macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization
Histone variants with metabolite-binding macrodomains provide a poorly understood link between chromatin composition and metabolism. To address their contribution to physiological health, we have generated and analyzed mice exclusively lacking the histone variants macroH2A1.1, macroH2A1.2, or macroH...
ORGANISM(S): Mus musculus 
2025-09-19 | GSE254938 | GEO
GenomicsThe histone variant macroH2A1.1 regulates RNA Polymerase II paused genes within defined chromatin interaction landscapes.
The histone variant macroH2A1.1 regulates RNA Polymerase II paused genes within defined chromatin interaction landscapes.
PRJNA588052 | ENA
UnknownThe histone variant macroH2A1.1 regulates RNA polymerase II-paused genes within defined chromatin interaction landscapes.
Not available
S-EPMC9016624 | biostudies-literature
TranscriptomicsThe histone variant macroH2A1.1 regulates RNA Polymerase II paused genes within defined chromatin interaction landscapes.
The histone variant macroH2A1.1 plays a role in cancer development and metastasis. To determine the underlying molecular mechanisms, we mapped the genome-wide localization of endogenous macroH2A1.1 in the human breast cancer cell line MDA-MB 231. We demonstrate that macroH2A1.1 specifically binds to...
ORGANISM(S): Homo sapiens 
2022-03-31 | GSE140022 | GEO
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