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TranscriptomicsRegeneration of comparative genomic hybridization oligonucleotide microarrays with dimethylurea
Reuse of materials in DNA hybridization based methods has been known since the advent of Southern membranes. Array based comparative genomic hybridization is essentially Southern hybridization with multiple probes immobilized on a solid surface. We have shown that comparative genomic hybridization m...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-35740 | biostudies-arrayexpress
TranscriptomicsConcurrent DNA copy number alterations and mutations in genes related to maintenance of genome stability in uninvolved glandular tissue from breast cancer patients
Somatic mosaicism for DNA copy number alterations (SMC-CNA) is defined as gain or loss of chromosomal segments in mitotic cells within a single organism. As cells harboring SMC-CNA have the potential to undergo clonal expansion, SMC-CNA may be present in a substantial portion of cells in differentia...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-63623 | biostudies-arrayexpress
TranscriptomicsDecoding NF1 intragenic copy number changes
Genomic rearrangements may cause both Mendelian and complex disorders. Currently, several major mechanisms causing genomic rearrangements have been proposed such as non-allelic homologous recombination (NAHR), non-homologous end joining (NHEJ), fork stalling and template switching (FoSTeS) and micro...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-64869 | biostudies-arrayexpress
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