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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
TranscriptomicsSpermidine Yeast Aging Array
Administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extends the lifespan of various model organisms including yeast, flies and worms. In ageing yeast, spermidine treatment triggeres epigenetic deacetylation of histone H3 through...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-04 | E-MTAB-912 | biostudies-arrayexpress
UnknownNicotinamide for the treatment of heart failure with preserved ejection fraction.
Not available
S-EPMC7611499 | biostudies-literature
UnknownClassification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases.
Not available
S-EPMC7325697 | biostudies-literature
TranscriptomicsEffects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Calorie restriction (CR) is the most robust non-genetic intervention to universally delay the onset of age-related diseases and extend mean and maximum lifespan. However, species, strain, sex, diet, age of onset, and level of CR are emerging as important variables to consider for a successful CR res...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-81959 | biostudies-arrayexpress
UnknownThe HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity
Not available
S-SCDT-EMM-2021-13952 | biostudies-other
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