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TranscriptomicsExpression data from control and LRF-deficient mouse germinal center B cells
B cells are indispensable for humoral immunity, as they ultimately give rise to antibody-secreting plasma cells. During T cell-dependent antibody responses, naive B cells form germinal centers (GCs), a distinct histologic structure found in secondary lymphoid organs. Naive B cells become activated u...
ORGANISM(S): Mus musculus 
2011-04-08 | E-GEOD-28449 | biostudies-arrayexpress
TranscriptomicsThe LRF/ZBTB7A transcription factor is a BCL11A-independent repressor of fetal hemoglobin
Hemoglobinopathies, including sickle cell disease and _-thalassemia, are global public health concerns. Induction of fetal-type hemoglobin (HbF) is a promising means to treat these disorders; however, precisely how HbF expression is silenced in adult erythroid cells is not fully understood. Here, we...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-74977 | biostudies-arrayexpress
TranscriptomicsExpression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs
LRF, which is encoded by the ZBTB7A gene and formerly known as POKEMON (POK erythroid myeloid ontogenic factor), was originally identified as a PLZF (promyelocytic leukemia zinc finger) homologue interacting with BCL6 (B-cell lymphoma 6). LRF is a transcription factor that is broadly expressed in he...
ORGANISM(S): Mus musculus 
2012-10-26 | E-GEOD-41839 | biostudies-arrayexpress
TranscriptomicsIntegrated copy number and expression analysis identifies profiles of whole-arm chromosomal alterations and subgroups with favorable outcome in ovarian clear cell carcinomas
Ovarian clear cell carcinoma (CCC) is generally associated with chemoresistance and poor clinical outcome, even with early diagnosis; whereas high-grade serous carcinomas (SCs) and endometrioid carcinomas (ECs) are commonly chemosensitive at advanced stages. Although an integrated genomic analysis o...
ORGANISM(S): Homo sapiens 
2015-05-11 | E-GEOD-65986 | biostudies-arrayexpress
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