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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
MetabolomicsAn untargeted metabolomics approach to characterize short-term and long-term metabolic changes after bariatric surgery
Bariatric surgery is currently one of the most effective treatments for obesity and leads to significant weight reduction, improved cardiovascular risk factors and overall survival in treated patients. To date, most studies focused on short-term effects of bariatric surgery on the metabolic profile ...
2015-09-15 | MTBLS218 | MetaboLights
TranscriptomicsRNA sequencing in fly heads to examine the effect of spermidine feeding on transcription in the ageing fly brain.
mRNA sequencing was used to identify genome wide transcriptional changes occuring in fly heads in response to spermidine feeding. This study shed light on the molecular mechanisms through wich spermidine can protect against age-dependent memory impairment. mRNA profiles from 3 and 10 day old Drosoph...
ORGANISM(S): Drosophila melanogaster 
2013-09-01 | E-GEOD-38998 | biostudies-arrayexpress
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