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TranscriptomicsA nuclear-localized red fluorescence knock-in reporter allele for mouse pancreatic beta-cells
In this study, we generated a novel nuclear-localized red fluorescence knock-in reporter allele (Ins2.Apple) for mouse pancreatic beta-cells. Beta-cells were isolated by FACS from 60-day-old mice, segregated by sex, and RNA-sequencing was performed to assess sex-specific differences in beta-cell gen...
ORGANISM(S): Mus musculus 
2018-12-15 | E-MTAB-6329 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome analysis of Sox17.Epi and Endo cells in mouse embryos
This experiment has been done to understand the dynamics of gene expression in Sox17.Epi and Endo cells using multiplex RNA-Seq technology. Sox17.Epi (Sox17^GFP+EpCAM+) and Sox17.Endo (Sox17^GFP+EpCAM-) cells were isolated by FACS from E9.5 mouse embryos. The spatial comparison between Sox17.Epi ver...
ORGANISM(S): Mus musculus 
2012-07-20 | E-MTAB-970 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of E15.5 mouse Insm1, Neurod1 and Pax6 knockouts vs Insm1GFP.Cre/+ controls
This experiment used RNA-Seq technology to explore gene expression in mouse Insm1GFP.Cre/+ controls and Insm1 (Insm1GFP.Cre/GFP.Cre), Neurod1 (Insm1GFP.Cre/+; Neurod1LacZ/LacZ), or Pax6 (Insm1GFP.Cre/+; Pax6fl/fl) knockout FACS sorted pancreatic endocrine cells at E15.5. Comparison of Insm1GFP.Cre+/...
ORGANISM(S): Mus musculus 
2021-08-23 | E-MTAB-10262 | biostudies-arrayexpress
TranscriptomicsDynamic Ca2+-dependent transcription links metabolic stress to impaired β-cell identity
Sustained stimulation and elevations in intracellular Ca2+ concentrations due to metabolic stress in pre-diabetic states triggers gene expression changes contributing to the loss of pancreatic β-cell function. To establish a temporal relationship between β-cell stimulation and perturbations in Ca2+...
ORGANISM(S): Mus musculus 
2025-05-22 | E-MTAB-14642 | biostudies-arrayexpress
TranscriptomicsTranscriptional regulation of endocrine cell differentiation by Insm1
This experiment used RNA-Seq technology to explore gene expression in mouse Insm1^GFP/Pdx1^CFP HIGH [het/het] FACS sorted pancreatic cells (pre-beta cells) and Insm1^GFP/Pdx1^CFP LOW [het/het] cells (other endocrine progenitors) at E15.5 and E18.5. Comparison of Insm1 +/Pdx HIGH and Insm1 +/Pdx LO...
ORGANISM(S): Mus musculus 
2014-07-01 | E-MTAB-1929 | biostudies-arrayexpress
UnknownGhrelin expression in the mouse pancreas defines a unique multipotent progenitor population.
Not available
S-EPMC3520898 | biostudies-literature
TranscriptomicsDisruption of PPARg signaling results in mouse prostatic intraepithelial neoplasia (mPIN) involving active autophagy
Peroxisome proliferator-activated receptor-gamma (PPARg) regulates the interface between cellular lipid metabolism, redox status and organelle differentiation. Following conditional prostatic epithelial knockout of PPARg in mice we observed focal hyperplasia of the epithelium which developed to mous...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-13867 | biostudies-arrayexpress
UnknownMethotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial.
Not available
S-EPMC4486345 | biostudies-literature
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