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ProteomicsSETD1A protects from senescence through regulation of the mitotic gene expression program
SETD1A, a Set1/COMPASS family member maintaining histone-H3-lysine-4 (H3K4) methylation on transcriptionally active promoters, is overexpressed in breast cancer. Here we show that SETD1Asupports mitotic processes and consequentially, its knockdown induces senescence, independent of mutations in p53,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-05-09 | MSV000083763 | MassIVE
TranscriptomicsmicroRNA Profiling in Wilms Tumors and Kidney Tissues
The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. The expression levels of microRNAs were profiled in 20 human Wilms tumor samples (WT), 3 human normal adult kidney samples (AK) and 5 human fetal kidney samples (FK) using a Luminex bea...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-50505 | biostudies-arrayexpress
TranscriptomicsCirculating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Cell Composition
By applying RNA-ISH and RNAseq to circulating tumor cells (CTCs), the study provides definitive evidence of epithelial to mesenchymal transition (EMT) across all histological types of breast cancer, identifying mediators such as FOXC1 and TGF-β signaling, and demonstrating dynamic treatment-associat...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-41245 | biostudies-arrayexpress
TranscriptomicsHER2 expression identifies dynamic functional states within circulating breast cancer cells
Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensit...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-75367 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of circulating tumour cells implicates WNT signaling in pancreatic cancer metastasis (mouse data)
Circulating tumour cells (CTCs) shed into blood from primary cancers include putative precursors that initiate distal metastases. While these cells are extraordinarily rare, they may identify cellular pathways contributing to the blood-borne dissemination of cancer. Here, we adapted a microfluidic d...
ORGANISM(S): Mus musculus 
2012-08-17 | E-GEOD-40171 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of circulating tumour cells implicates WNT signaling in pancreatic cancer metastasis (human data)
Circulating tumour cells (CTCs) shed into blood from primary cancers include putative precursors that initiate distal metastases. While these cells are extraordinarily rare, they may identify cellular pathways contributing to the blood-borne dissemination of cancer. Here, we adapted a microfluidic d...
ORGANISM(S): Homo sapiens 
2012-08-17 | E-GEOD-40174 | biostudies-arrayexpress
TranscriptomicsSingle Cell RNA-sequencing of Pancreatic Circulating Tumor Cells
Circulating Tumor Cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. Using a pancreatic cancer mouse model, we applied a microfluidic device to isolate CTCs independently of tumor epitopes, subjecting these to single cell RN...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-51372 | biostudies-arrayexpress
ProteomicsCDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors
BRx82 and BRx142 were cell cultures derived from breast cancer circulating tumor cells and propagated ex-vivo. To study early changes that transpire under mitosis inhibiting chemotherapy, these cultures were subjected to a 16 hours exposure to docetaxel (10nM or DMSO as vehicle control) and then cu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-03-05 | MSV000094243 | MassIVE
TranscriptomicsDynamic Chromatin Modification Sustains Epithelial-Mesenchymal Transition following Inducible Expression of Snail-1 (ChIP-chip)
Epithelial-Mesenchymal Transition (EMT) is thought to contribute to cancer metastasis, but its underlying mechanisms are not well understood. To define early steps in this cellular transformation, we analyzed human mammary epithelial cells with tightly regulated expression of Snail-1, a master regul...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-52591 | biostudies-arrayexpress
TranscriptomicsDynamic Chromatin Modification Sustains Epithelial-Mesenchymal Transition following Inducible Expression of Snail-1 (gene expression)
Epithelial-Mesenchymal Transition (EMT) is thought to contribute to cancer metastasis, but its underlying mechanisms are not well understood. To define early steps in this cellular transformation, we analyzed human mammary epithelial cells with tightly regulated expression of Snail-1, a master regul...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-52592 | biostudies-arrayexpress
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