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ProteomicsExtracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer
Background: Anaplastic thyroid cancer (ATC) is an aggressive and rare disease. Rapid metastasis and limited promising treatments call for additional therapeutic options, including drug repurposing. The early spreading of ATC highlights the importance of rapid therapy success assessment, which could ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD064007 | Pride
Anaplastic thyroid cancer Vandetanib Extracellular vesicles Dose-dependent transcriptomics and proteomics 
TranscriptomicsMYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.
MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive effects in MYCN-amplified neuroblastoma cells. In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-44538 | biostudies-arrayexpress
ProteomicsConsistency across multi-omics layers in a drug-perturbed gut microbial community
Here we map the molecular response of a synthetic community of 32 human gut bacteria to three non-antibiotic drugs by using five omics layers, namely 16S rRNA gene profiling, metagenomics, metatranscriptomics, metaproteomics, and metabolomics. Using this controlled setting, we find that all omics me...
ORGANISM(S): metagenome 
2022-12-13 | PXD036445 | Pride
Multi-omics proteomics metagenomics metatranscriptomics community drug chlorpromazine niclosamide metformin gut microbiome microbiota 
ProteomicsConserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota
Suppression of chronic Arabidopsis immune responses is a widespread but typically strain-specific trait across the major bacterial lineages of the plant microbiota. Here, through phylogenetic analysis of 1,765 Xanthomonadales genomes, we show that immunomodulation is a highly conserved, ancestral tr...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-12-12 | PXD045054 | Pride
Innate immunity Xanthomonadales Clearance of immunogenic peptide Immunomodulation Plant microbiota 
TranscriptomicsGenome-wide promoter methylation analysis of human melanocytes and melanoma cell lines
DNA methylation profiling of human melanocytes and melanoma cell lines. Goal was to identify hypermethylated gene promoters in melanoma Genomic DNA from 4 human melanoma cell lines and normal human epidermal melanocytes was subjected to methylated DNA immunoprecipitation (MeDIP) and hybridized to Ag...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-53801 | biostudies-arrayexpress
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