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TranscriptomicsCLP1 links tRNA metabolism to progressive motor-neuron loss
CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1K/K) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of...
ORGANISM(S): Mus musculus 
2013-03-12 | E-GEOD-35924 | biostudies-arrayexpress
UnknownTau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease.
Not available
S-EPMC8168922 | biostudies-literature
TranscriptomicsFate and State Transitions during Human Blood Vessel Organoid Development: Time Course
Human blood vessel organoids (hBVOs) derived from human pluripotent stem cells have emerged as a novel system to understand human vascular development, model disorders, and develop regenerative therapies. However, it was unclear which molecular states constitute hBVOs and how cells differentiate and...
ORGANISM(S): Homo sapiens 
2025-03-21 | E-MTAB-14807 | biostudies-arrayexpress
TranscriptomicsFate and State Transitions during Human Blood Vessel Organoid Development: Perturbation
Human blood vessel organoids (hBVOs) have emerged as a system to model human vascular development and disease. Here, we use genetic and signaling pathway perturbations to reconstruct hBVO development. We use single-cell genetic perturbations to identify transcription factors (TFs) and receptors invo...
ORGANISM(S): Homo sapiens 
2025-03-01 | E-MTAB-14839 | biostudies-arrayexpress
UnknownQuantitative historical analysis uncovers a single dimension of complexity that structures global variation in human social organization.
Not available
S-EPMC5777031 | biostudies-literature
UnknownGuidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Not available
S-EPMC7350392 | biostudies-literature
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