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UnknownPostinterventional fetal aortic regurgitation: prevalence, outcome and effects on fetal circulation in large single-center cohort.

Objectives

To analyze the prevalence and severity of fetal aortic regurgitation (AR) after undergoing successful fetal aortic valvuloplasty (FAV) and to evaluate its effects on fetal circulation and left ventricular (LV) growth.

Methods

This was a retrospective review of all fetuses w...
S-EPMC11872343 | biostudies-literature
UnknownDiscovery of an unusually high number of de novo mutations in sperm of older men using duplex sequencing.
De novo mutations (DNMs) are important players in heritable diseases and evolution. Of particular interest are highly recurrent DNMs associated with congenital disorders that have been described as selfish mutations expanding in the male germline, thus becoming more frequent with age. Here, we have ...
S-EPMC8896467 | biostudies-literature
UnknownClinical characteristics, molecular reclassification trajectories and DNA methylation patterns of long- and short-term survivors of WHO grade II and III glioma.

Purpose

The prognosis of diffuse gliomas previously classified as "lower-grade" is heterogeneous and complicates clinical decisions. We aimed to investigate the molecular profile of clinical outliers to gain insight into biological drivers of long and short-term survivors.

Methods

Her...
S-EPMC11829921 | biostudies-literature
TranscriptomicsCLP1 links tRNA metabolism to progressive motor-neuron loss
CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1K/K) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of...
ORGANISM(S): Mus musculus 
2013-03-12 | E-GEOD-35924 | biostudies-arrayexpress
MetabolomicsDissecting Metabolism of Leaf Nodules in Ardisia crenata and Psychotria punctata
Root-microbe interaction and its specialized root nodule structures and functions are well studied. In contrast, leaf nodules harboring microbial endophytes in special glandular leaf structures have only recently gained increased interest as plant-microbe phyllosphere interactions. Here, we applied ...
2021-08-26 | MTBLS2870 | MetaboLights
UnknownModulation of cell fate by shock wave therapy in ischaemic heart disease.

Aims

Cardiac shockwave therapy (SWT) improves left ventricular (LV) function in patients with ischaemic cardiomyopathy. Shockwave therapy activates Toll-like receptor 3 (TLR3), a receptor-inducing chromatin remodelling and nuclear reprogramming of cardiac cells. We hypothesized that mechanic...
S-EPMC11977462 | biostudies-literature
UnknownPreclinical Assessment of Atorvastatin for Treatment of Endocardial Fibroelastosis.
Endocardial fibroelastosis is a condition caused by the fibrogenic activation of endothelial cells via endothelial-to-mesenchymal transition of the endocardium, which is regulated by the transforming growth factor-β pathway. Atorvastatin, a statin, can protect the vascular endothelium by up-regulati...
S-EPMC12539480 | biostudies-literature
UnknownHigh prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing.
The mammary gland undergoes hormonally stimulated cycles of proliferation, lactation, and involution. We hypothesized that these factors increase the mutational burden in glandular tissue and may explain high cancer incidence rate in the general population, and recurrent disease. Hence, we investiga...
S-EPMC9243094 | biostudies-literature
UnknownTrabectedin for recurrent WHO grade 2 or 3 meningioma: A randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG).

Background

No systemic treatment has been established for meningioma progressing after local therapies.

Methods

This randomized, multicenter, open-label, phase II study included adult patients with recurrent WHO grade 2 or 3 meningioma. Patients were 2:1 randomly assigned to intraveno...
S-EPMC9071312 | biostudies-literature
UnknownGuidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are ...
S-EPMC7350392 | biostudies-literature
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