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TranscriptomicsMajor Depressive Disorder blood gene expression
Background: Major Depressive Disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are not available. Methods: We used a classifier approach on blood gene expression profiles of a unique set of non-medicated su...
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-19738 | biostudies-arrayexpress
GenomicMajor Depression: Stage 1 Genomewide Association in Population-Based Samples

Identification of genomic regions that confer susceptibility to or protection from major depressive disorder (MDD) via genomewide association.

Consent groups and participant set

  • Psychiatric and Related Somatic Conditions (PRSC): 3741 (1821 cases, 1822 contro...
phs000020 | dbGaP
GenomicIntegration of Genomics and Transcriptomics in unselected Twins and in Major Depression

Our goals are to develop a comprehensive understanding of the genomics of transcription in a population based unselected sample and to discover DNA and RNA biomarkers for major depressive disorder (MDD). This work is essential to developing a more complete understanding of the biological basis of...

phs000486 | dbGaP
UnknownComorbidity-age index: a clinical measure of biologic age before allogeneic hematopoietic cell transplantation.
Not available
S-EPMC4178523 | biostudies-literature
ProteomicsCryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation
Protein degradation, a major eukaryotic response to cellular signals, is subject to numerous layers of regulation. In yeast, the evolutionarily conserved GID E3 ligase mediates glucose-induced degradation of fructose-1,6-bisphosphatase (Fbp1) and other gluconeogenic enzymes. “GID” is a collection of...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-05-29 | PXD028579 | Pride
Gid E3 ligase complex Crzoem 
GenomicsNHLBI Jackson Heart Study Candidate Gene Association Resource (CARe)

The Jackson Heart Study (JHS) is a large, community-based, observational study whose participants were recruited from urban and rural areas of the three counties (Hinds, Madison and Rankin) that make up the Jackson, Mississippi, metropolitan statistical area (MSA). Participants were enrolled f...

phs000286.v2.p1 | EGA
ProteomicsCullin-RING ligases target substrates with geometrically optimized catalytic partners
Cullin-RING ubiquitin ligases (CRLs) control the degradation of a wide landscape of human proteins in combination with ubiquitin-carrying enzymes (UCEs). CRL expansion during evolution is apparent, with a few dozen in yeast that function with a single UCE and as many as 300 in humans that function w...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD043523 | Pride
Ubiquitylation Cullin-ring ligase 
TranscriptomicsGene expression profiling of chronic lung disease for the Lung Genomics Research Consortium
Microarray data from total RNA extracted from whole lung homogenate from subjects undergoing thoracic surgery. These subjects were diagnosed as being controls or having interstitial lung disease or COPD as determined by clinical history, CT scan, and surgical pathology. There was no intervention, th...
ORGANISM(S): Homo sapiens 
2013-05-30 | E-GEOD-47460 | biostudies-arrayexpress
UnknownA fully iPS-cell-derived 3D model of the human blood-brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions.
Not available
S-EPMC12880921 | biostudies-literature
UnknownProtocol for validating an algorithm to identify neurocognitive disorders in Canadian Longitudinal Study on Aging participants: an observational study.
Not available
S-EPMC10626860 | biostudies-literature
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