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TranscriptomicsGene Expression in Frontal Cortex in Major Depression and HIV
Major depressive disorder (MDD) is a clinically defined entity with little understanding as to the underlying pathological substrate. Biologically, MDD is characterized by disruption of neurotransmitters, especially serotonin and noradrenaline, which are the main targets of antidepressants. We pre...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-17440 | biostudies-arrayexpress
UnknownMetabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.
Not available
S-EPMC8525586 | biostudies-literature
MetabolomicsIntegration of metabolomics, genomics and immune phenotypes reveals the causal roles of metabolites in disease

BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.

RESULT: We systematically investigate circulating metabolites in a cohort of 5...

2021-06-14 | MTBLS2633 | MetaboLights
MetabolomicsDevelopment and validation of a liquid chromatography-electrospray ionization-time-of-flight mass spectrometry method for induced changes in Nicotiana attenuata leaves during simulated herbivory
Metabolite profiling of herbivory-induced changes in Nicotiana attenuata was used to construct a correlation-weighted network to visualize intra- and inter-compound spectra relationships from individual mass features, and to annotate 12 major network hubs, including 4 O-acyl sugars and 6 17-hydroxyg...
2012-08-14 | MTBLS10 | MetaboLights
MetabolomicsSpecific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata
The native diploid tobacco Nicotiana attenuata produces abundant, potent anti-herbivore defense metabolites known as 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs) whose glycosylation and malonylation biosynthetic steps are regulated by jasmonate signaling. To characterize the biosyntheti...
2021-10-06 | MTBLS1819 | MetaboLights
TranscriptomicsThe retinoblastoma orthologue, rblA, is a major regulator of S-phase, mitotic, and developmental gene expression in Dictyostelium
The retinoblastoma tumour suppressor, Rb, has two major functions. First, it represses genes whose products are required for S-phase entry and progression, thus stabilizing cells in G1. Second, Rb synergizes with factors that induce cell cycle exit and terminal differentiation. Dictyostelium lacks a...
ORGANISM(S): Dictyostelium discoideum 
2012-05-17 | E-GEOD-30368 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response to substrate and temperature in two thermophilic fungi, Myceliophthora thermophila and Thielavia terrestris, and a related mesophile, Chaetomium globosum
The thermophilic filamentous fungi Myceliophthora thermophila (Sporotrichum thermophile) and Thielavia terrestris are proficient decomposers of cellulose, suggesting that they will be a rich source of thermostable industrial enzymes for lignocellulose degradation. To identify the genes and proteins...
ORGANISM(S): Myceliophthora thermophila 
2011-08-08 | E-GEOD-27323 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hypothalamus, liver, kidney, ovaries and testis from male and female humans and mice
Compared differentially express genes by sex in mouse for the following tissues: hypothalamus, liver, kidney, ovaries and testis (3 biological x 2 technical replicates for each tissues/sex). We used Affymetrix MOE430A Genechip arrays.
ORGANISM(S): Homo sapiens 
2007-03-21 | E-MEXP-114 | biostudies-arrayexpress
TranscriptomicsThe effects of prostaglandin E2 on the gene expression of human natural killer cells
Tumour immune escape is a major factor contributing to cancer progression and unresponsiveness to cancer therapies. Tumours can produce prostaglandin E2 (PGE2), an inflammatory mediator that directly acts on NK cells to inhibit anti-tumour immunity. However, it is unclear precisely how PGE2 influenc...
ORGANISM(S): Homo sapiens 
2023-11-28 | E-MTAB-13106 | biostudies-arrayexpress
UnknownIntestinal absorption of fluorescently labeled nanoparticles.
Not available
S-EPMC4476919 | biostudies-literature
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