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TranscriptomicsN and S regulation of wheat storage protein accumulation
Seed storage proteins (SSP) play a central role in providing carbon (C), nitrogen (N), and sulfur (S) resources during seed germination. Their content and composition are essential determinants shaping wheat end-use value. Molecular mechanisms underlying the developmental and nutritional regulation ...
ORGANISM(S): Triticum aestivum 
2015-06-15 | E-MTAB-1782 | biostudies-arrayexpress
ProteomicsStructural, molecular and cellular impact of the Ogden syndrome mutant N-terminal acetyltransferase hNaa10-Ser37Pro
Abstract still has to be written. The obtained peptide mixtures were introduced into an LC-MS/MS system, the Ultimate 3000 (Dionex, Amsterdam, The Netherlands) in-line connected to an LTQ Orbitrap XL mass spectrometer (Thermo Fisher Scientific, Bremen, Germany). Samples were first loaded on a trapp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-13 | MSV000083564 | MassIVE
MetabolomicsPlasma 1H-NMR metabolic and amino acid profiles of newborn piglets from two lines divergently selected for residual feed intake

Together with environmental factors, physiological maturity at birth is a major determinant for neonatal survival and postnatal development in mammalian species. Maturity at birth is the outcome of complex mechanisms of intra-uterine development and maturation during the end of gestation. In pig ...

2023-02-16 | MTBLS2137 | MetaboLights
ProteomicsSweet and sour Ehrlichia: glycoproteomics and phosphoproteomics reveal new players in Ehrlichia ruminantium physiology and pathogenesis
Unraveling which proteins and PTMs affect bacterial pathogenesis and physiology in diverse environments is a tough challenge. Herein, we used mass spectrometry-based assays to study protein phosphorylation and glycosylation in Ehrlichia ruminantium Gardel virulent (ERGvir) and attenuated (ERGatt) va...
ORGANISM(S): Ehrlichia ruminantium str. Gardel 
2019-03-01 | PXD012589 | Pride
Ehrlichia species  phosphoproteins  s/t/y phosphorylation  n-glycoproteins  o-glcnacylated proteins  bacteria physiology  pathogenesis 
ProteomicsExtended multiplexing of TMT labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue
Age-related and/or high caloric intake driven changes in visceral adipose tissue contribute to the development of diabetes and cardiovascular disease. The lack of reliable, high-throughput methods to analyze the adipose tissue protein composition has limited our understanding of the protein network...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-07-03 | MSV000082569 | MassIVE
GenomicsHigh Resolution Mapping of H1 Linker Histone Variants in Embryonic Stem Cells
H1 linker histones facilitate higher order chromatin folding and are essential for mammalian development. To achieve high resolution mapping of H1 variants H1d and H1c in embryonic stem cells (ESCs), we have established a knock-in system and shown that the N-terminally tagged H1 proteins are functi...
ORGANISM(S): Mus musculus 
2013-04-29 | E-GEOD-46134 | biostudies-arrayexpress
TranscriptomicsExpression profiles of the hippocampus of Rsk2-KO mice
Coffin–Lowry Syndrome (CLS) is a syndromic form of mental retardation caused by loss of function mutations in the X-linked RPS6KA3 gene, which encodes Rsk2, a serine/threonine kinase involved in spatial memory. We analyzed hippocampal gene expression profiles in Rsk2-KO mice to identify changes in ...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-22137 | biostudies-arrayexpress
TranscriptomicsA natural expression variant reveals a novel mechanism of insect resistance in boreal forest trees.
We report the discovery of a beta-glucosidase gene (PgM-NM-2glu-1) whose expression underpins natural resistance to a major forest pest, the spruce budworm (SBW) in white spruce (Picea glauca (Voss.) Moench). We performed a microarray experiment to compare resistant (R) and non-resistant (N-R) trees...
ORGANISM(S): Picea glauca 
2014-05-06 | E-GEOD-57301 | biostudies-arrayexpress
TranscriptomicsProtease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
During chronic liver disease, tissue remodeling leads to dramatic changes and accumulation of matrix components. Matrix metalloproteases and their inhibitors have been involved in the regulation of matrix degradation. However, the role of other proteases remains incompletely defined. We undertook a ...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-24667 | biostudies-arrayexpress
UnknownBosutinib Versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia: Results From the Randomized BFORE Trial.
Not available
S-EPMC5966023 | biostudies-literature
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