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UnknownOncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently.
Earlier we showed that human genome contains many evolutionarily young or novel genes with tumor-specific or tumor-predominant expression. We suggest calling such genes Tumor Specifically Expressed, Evolutionarily New (TSEEN) genes. In this paper we performed a study of the evolutionary ages of diff...
S-EPMC6848199 | biostudies-literature
UnknownSubtypes of Neurohypophyseal Nonapeptide Receptors and Their Functions in Rat Kidneys.
The nonapeptides of neurohypophysis, vasotocin and mesotocin, detected in most vertebrates, are replaced by vasopressin and oxytocin in mammals. Using bioinformatics methods, we determined the spectrum of receptor subtypes for these hormones in mammals and their physiological effects in the kidneys ...
S-EPMC7245957 | biostudies-literature
UnknownA new cancer/testis long noncoding RNA, the OTP-AS1 RNA.
The orthopedia homeobox (OTP) gene encodes a homeodomain-containing transcription factor involved in brain development. OTP is mapped to human chromosome 5q14.1. Earlier we described transcription in the second intron of this gene in wide variety of tumors, but among normal tissues only in testis. I...
S-EPMC11576910 | biostudies-literature
UnknownEvolutionarily novel genes are expressed in transgenic fish tumors and their orthologs are involved in development of progressive traits in humans.

Abstract

Earlier we suggested a new hypothesis of the possible evolutionary role of hereditary tumors (Kozlov, Evolution by tumor Neofunctionalization, 2014), and described a new class of genes - tumor specifically expressed, evolutionarily novel (TSEEN) genes - that are predicted by ...
S-EPMC6896781 | biostudies-literature
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