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TranscriptomicsMolecular reprogramming of primary human resting memory CD4+ T cells by HIV-1 Vpr
Resting CD4+ T cells are infected by HIV-1 in vivo, however are refractory to cell-free HIV-1 infection in vitro. We show that they are efficiently infected by cell-to-cell spread. To allow resting T cell infection, uninfected resting target cells were co-cultured with infected donor T cells. Cells ...
ORGANISM(S): Homo sapiens 
2022-03-31 | E-MTAB-11454 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse T cell model to characterize transendothelial migration across lymphatics
Sphingosine 1-phosphate (S1P) influences T cell migration into and out of secondary lymphoid organs; however, its mechanism of action remains uncertain. Our previous research shows that agonism of the S1P receptor S1P1 inhibits the egress of T lymphocytes from the peripheral tissues into afferent ly...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9237 | biostudies-arrayexpress
TranscriptomicsExamination of inflammatory transcripts during a transfer model of type I diabetes.
In an accompanying paper we found specific localization of diabetogenic T cells only to islets of Langerhans bearing the specific antigen. Instrumental in the specific localization was the presence of intra-islet dendritic cells bearing the β-cell-peptide-MHC complex. Here we report that the entry o...
ORGANISM(S): Mus musculus 
2011-02-16 | E-GEOD-26147 | biostudies-arrayexpress
TranscriptomicsPlac8-dependent and iNOS-dependent T cell-mediate mechanisms clear Chlamydia muridarum infections from the genital tract
Comparison of two Chlamydia-specific CD4 T cells that are dependent on iNOS to terminate Chlamydia replication in epithelial cells to two Chlamydia-specific CD4 T cells that are iNOS-independent: Chlamydia trachomatis urogenital serovars replicate predominately in epithelial cells lining the reprod...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-32128 | biostudies-arrayexpress
UnknownCrystallization and preliminary crystallographic study of the yeast Malassezia sympodialis allergen Mala s 1.
Not available
S-EPMC2150955 | biostudies-literature
UnknownMalassezia sympodialis Mala s 1 allergen is a potential KELCH protein that cross reacts with human skin.
Not available
S-EPMC10281499 | biostudies-literature
TranscriptomicsMicroarray expression profiling of NKT and MAIT subsets in different organs of B6-MAIT/CAST mice.
MAIT cells (MAITs) represent an abundant T lymphocyte subset with unique specificity for microbial metabolites presented by the MHC-1b molecule, MR1. MAIT conservation along evolution indicates important, non-redundant functions, but their low frequency in mice has hampered their detailed characteri...
ORGANISM(S): Mus musculus 
2018-12-03 | E-MTAB-7133 | biostudies-arrayexpress
UnknownLongitudinal and Transverse Relaxivity Analysis of Native Ferritin and Magnetoferritin at 7 T MRI.
Not available
S-EPMC8395175 | biostudies-literature
TranscriptomicsMolecular profiling of tumor-specific Th1 cells activated in vivo
Expression data from mouse tumor-specific CD4+ T cells The central role of tumor-specific Th1 cells in fighting cancer is becoming increasingly appreciated. However, little is known about how these cells are generated in vivo. Here, we used flow cytometry and gene expression microarrays to character...
ORGANISM(S): Mus musculus 
2013-05-15 | E-GEOD-46453 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of intraepithelial and peripheral CTL from patients with celiac disease or cytomegalovirus seropositive patients suggest that a stepwise transformation of CTLs into NK-like cells may underlie immunopathology in various chronic infectious and inflammatory diseases.
Celiac disease is an intestinal inflammatory disorder induced by dietary gluten in genetically susceptible individuals. The mechanisms underlying the massive expansion of interferon g–producing intraepithelial cytotoxic T lymphocytes (CTLs) and the destruction of the epithelial cells lining the sm...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4592 | biostudies-arrayexpress
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