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ProteomicsHypoxic injury triggers maladaptive repair in human kidney organoids
Reduction in blood supply to the kidneys occurs to certain extent during kidney injury (AKI). Individuals who suffered AKI are at risk of developing chronic kidney disease (CKD) through a maladaptive repair process. At present, no therapies exist to prevent the AKI to CKD transition. Here, we presen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-26 | PXD042882 | Pride
Acute kidney injury Metabolomics Organoids Chronic kidney disease Transcriptomics Maladaptive regeneration Proteomics Hypoxia 
GenomicsMALADAPTIVE IMMUNE-FIBROTIC AXIS DRIVES IMPAIRED LONG BONE REGENERATION UNDER MECHANICAL INSTABILITY
MALADAPTIVE IMMUNE-FIBROTIC AXIS DRIVES IMPAIRED LONG BONE REGENERATION UNDER MECHANICAL INSTABILITY
PRJNA1494448 | ENA
GenomicsHypoxic injury triggers maladaptive repair in human kidney organoids
Hypoxic injury triggers maladaptive repair in human kidney organoids
PRJNA1167786 | ENA
GenomicsHypoxic injury triggers maladaptive repair in human kidney organoids [scRNA-seq]
Hypoxic injury triggers maladaptive repair in human kidney organoids [scRNA-seq]
PRJNA1013406 | ENA
TranscriptomicsHypoxic injury triggers maladaptive repair in human kidney organoids [scRNA-seq]
Reduction in blood supply to the kidneys occurs to certain extent during acute kidney injury (AKI). Individuals who suffered AKI are at risk of developing chronic kidney disease (CKD) through a maladaptive repair process. Currently, the lack of a reliable research model that allows the characterizat...
ORGANISM(S): Homo sapiens 
2025-08-15 | GSE242425 | GEO
TranscriptomicsHypoxic injury triggers maladaptive repair in human kidney organoids
Acute kidney injury (AKI) is a common clinical disorder linked to high rates of illness and death. Ischemia is a leading cause of AKI, which can result in chronic kidney disease (CKD) through a maladaptive repair process characterised by failed epithelial regeneration, inflammation, and metabolic dy...
ORGANISM(S): Homo sapiens 
2026-04-20 | GSE278562 | GEO
OtherMALADAPTIVE IMMUNE-FIBROTIC AXIS DRIVES IMPAIRED LONG BONE REGENERATION UNDER MECHANICAL INSTABILITY
Delayed and non-healing fractures, affecting 5–10% of cases, are associated with prolonged disability and diminished quality of life. Although acute inflammation is required to initiate repair, persistent mechanical instability can sustain maladaptive immune and fibrotic responses that impede regene...
ORGANISM(S): Mus musculus 
2026-09-01 | GSE338404 | GEO
UnknownTGF-β1-triggered maladaptive bone marrow endothelium impedes hematopoietic recovery.
Not available
S-EPMC12500950 | biostudies-literature
TranscriptomicsImmunohistochemical Investigation for Renal Tubules in Adaptive and Maladaptive Repair Process after Renal Tubular Injury in the Kidney of Rats
Acute kidney injury (AKI) have been thought to be reversible condition, however, emerging evidence demonstrated association between AKI and subsequent development of irreversible fibrosis and chronic kidney disease. In the present study, since recovery of AKI depends on renal tubular regeneration, f...
ORGANISM(S): Rattus norvegicus 
2020-06-01 | GSE148420 | GEO
UnknownPrecision nanotherapeutics for kidney disease: targeting inflammation and maladaptive repair.
Not available
S-EPMC12935853 | biostudies-literature
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