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TranscriptomicsTranscription profiling of human tissue samples to identify novel genes associated with malignant melanoma but not benign melanocytic lesions
A number of melanoma specific genes were identified to differentiate clinical relevant tissue samples containing benign from malignant melanocytes. Experiment Overall Design: 7 normal skin, 18 nevi and 45 melanoma samples
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3189 | biostudies-arrayexpress
TranscriptomicsMicroRNA Expression Profiles Associated with Mutational Status and Survival in Malignant Melanoma
In order to improve our understanding of microRNA (miRNA) deregulation in melanoma development and possible consequences for patient survival, miRNA expression profiles were determined, using an array based approach, in melanoma tumors, melanoma cell lines and normal melanocytes. Differentially expr...
ORGANISM(S): Homo sapiens 
2010-04-21 | E-GEOD-19387 | biostudies-arrayexpress
TranscriptomicsVEGFR-1 expressed by malignant melanoma initiating cells is required for tumor growth
Melanoma growth is driven by malignant melanoma initiating cells (MMIC) identified by expression of the ATP-binding cassette (ABC) member, ABCB5. ABCB5+ melanoma subpopulations have been shown to overexpress the vasculogenic differentiation markers CD144 (VE-cadherin) and TIE-1 and are associated...
ORGANISM(S): Homo sapiens 
2011-01-13 | E-GEOD-26569 | biostudies-arrayexpress
TranscriptomicsElectric pulses do not change expression profile of genes involved in development of cancer in malignant melanoma cells
Electroporation is a versatile method for in vitro or in vivo delivery of different molecules into cells. However, no study so far has analysed the effects of electric pulses used in electrochemotherapy (ECT pulses) or electric pulses used in electrogene therapy (EGT pulses) on malignant cells. We s...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-15420 | biostudies-arrayexpress
TranscriptomicsClinical relevance of SKP2 alterations in metastatic melanoma
Melanoma cell lines were genotyped to evaluate copy number differences between nodular melanoma (NM) and superficial spreading melanoma (SSM). Cell lines were also evaluated for copy number alterations in the SKP2/p27 axis. Affymetrix SNP arrays were performed according to manufacturer's instruction...
ORGANISM(S): Homo sapiens 
2010-10-21 | E-GEOD-22305 | biostudies-arrayexpress
GenomicsThe histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
The most common mutation in human melanoma, BRAF(V600E), activates the serine/threonine kinase BRAF and causes excessive activity in the mitogen-activated protein kinase pathway. BRAF(V600E) mutations are also present in benign melanocytic naevi, highlighting the importance of additional genetic alt...
ORGANISM(S): Homo sapiens 
2011-03-25 | E-GEOD-28170 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human melanoma cell lines treated with 5-Aza-2-deoxycytidine to identify novel tumor suppressor genes silenced by methylation in melanoma
Malignant melanoma is a common and frequently lethal disease. Current therapeutic interventions have little effect on survival, emphasizing the need for a better understanding of the genetic, epigenetic, and phenotypic changes in melanoma formation and progression. We identified genes that were not ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9118 | biostudies-arrayexpress
ProteomicsA Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues, fractionated approach
Malignant melanoma has currently the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has previously has very limited possibilities to be cured. Recently, several protein kinase inhib...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-23 | MSV000080282 | MassIVE
ProteomicsA Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues, unfractionated approach
Malignant melanoma has currently the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has previously has very limited possibilities to be cured. Recently, several protein kinase inhib...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-23 | MSV000080280 | MassIVE
GenomicsLoss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
DNA methylation at the 5-position of cytosine (5-mC) is a key epigenetic mark critical for varius biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the Ten-Eleven Translocation (TET) family of DNA hydroxylases. Here we report that "loss of 5-hmC&...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-38231 | biostudies-arrayexpress
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