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MetabolomicsSexual dimorphism in the fetal cardiac response to maternal nutrient restriction
Poor maternal nutrition causes intrauterine growth restriction (IUGR); however, its effects on fetal cardiac development are unclear. We have developed a baboon model of moderate maternal undernutrition, leading to IUGR. We hypothesized that the IUGR affects fetal cardiac structure and metabolism. S...
2018-04-30 | MTBLS426 | MetaboLights
TranscriptomicsIdentification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Obesity
Maternal obesity programs the offspring to cardiovascular disease, insulin resistance, and obesity. We sequenced and profiled the cardiac miRNAs that were dysregulated in the hearts of baboon fetuses born to a high fat / high fructose diet fed mothers compared to a regular diet fed mothers. Fetal he...
ORGANISM(S): Papio hamadryas 
2013-02-01 | E-GEOD-43323 | biostudies-arrayexpress
TranscriptomicsIdentification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Undernutrition
Poor maternal nutrition during pregnancy causes intrauterine growth retardation, which, in turn, is associated with increased risk of cardiovascular and metabolic diseases in later life Fetal hearts were collected from baboon fetuses born to regularly fed and undernurished mothers. Total RNA was i...
ORGANISM(S): Papio hamadryas 
2015-11-02 | E-GEOD-69609 | biostudies-arrayexpress
ProteomicsIncreased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition
Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease. However, the progressive detrimental remodeling processes that relate altered blood flow...
ORGANISM(S): Gallus Gallus (ncbitaxon:9031) 
2019-07-17 | MSV000084103 | MassIVE
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