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TranscriptomicsTranscription profiling of human mammary epithelial cell lines with finite life span and immortal non-malignant cells - time series
Nonmalignant human mammary epithelial cells (HMEC) seeded in laminin-rich extracellular matrix (lrECM) form polarized acini and, in doing so, transit from a disorganized proliferating state to an organized growth-arrested state. We hypothesized that the gene expression pattern of organized and growt...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-8096 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of finite life span and immortal non-malignant human mammary epithelial cell lines
We analyzed gene expression in 184 (finite life span) and HMT3522 S1 (immortal non-malignant) HMECs on successive days (3, 5, and 7) post-seeding in a laminin-rich extracellular matrix assay. Both HMECs underwent growth arrest in G0/G1 and differentiated into polarized acini between days 5 and 7.
ORGANISM(S): Homo sapiens 
2007-03-15 | E-MEXP-1006 | biostudies-arrayexpress
UnknownCyclic AMP regulates formation of mammary epithelial acini in vitro.
Not available
S-EPMC3408423 | biostudies-literature
TranscriptomicsIdentification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells
Understanding transcriptional changes during cancer progression is of crucial importance to develop new and more efficacious diagnostic and therapeutic approaches. It is well known that ErbB2 is overexpressed in about 25% of human invasive breast cancers. We have previously demonstrated that p130Cas...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-42949 | biostudies-arrayexpress
ProteomicsNovel protocol for spatial proteome analysis of microdissected formalin-fixed paraffin-embedded tissues
Novel In-insert FFPE proteomics combines single glass insert FFPE tissue processing with spatial quantitative data-independent mass spectrometry (DIA). The method represents a potent protocol for spatial FFPE tissue subsection processing in combination with laser capture microdissection, achieving s...
ORGANISM(S): Homo sapiens (Human) 
2024-06-03 | PXD051706 | Pride
Human Limited proteomics Breast tissue Formalin-fixed paraffin-embedded tissue Mammary acini Exploris 480 Laser capture microdissection Spatial proteomics 
TranscriptomicsIdentification of genes responsive to change in apical polarity in the breast epithelium
Differentiation of monolayered epithelia is characterized by the formation of a basoapical polarity axis, except during the early stages of cancer development. Using mammary glandular structures (acini) produced in a three-dimensional cell culture system we have demonstrated that, in order for mamma...
ORGANISM(S): Homo sapiens 
2012-02-29 | E-GEOD-35165 | biostudies-arrayexpress
UnknownFunctional interactions between 17 β -estradiol and progesterone regulate autophagy during acini formation by bovine mammary epithelial cells in 3D cultures.
Not available
S-EPMC4033348 | biostudies-literature
UnknownHuman breast cancer cells are redirected to mammary epithelial cells upon interaction with the regenerating mammary gland microenvironment in-vivo.
Not available
S-EPMC3498340 | biostudies-literature
UnknownGene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer.
Not available
S-EPMC2933218 | biostudies-literature
TranscriptomicsChemokine expressions in breast cancer patients
Our aim was to evaluate the expression of chemokines in breast cancers before treatment to identify a molecular signature that could distinguish between women with or without cancer. We identified a panel of chemokines clearly deregulated in breast cancer that could be further investigated for prosp...
ORGANISM(S): Homo sapiens 
2011-11-05 | E-GEOD-33487 | biostudies-arrayexpress
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