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TranscriptomicsTranscription profiling of human breast cancer and a modular analysis of reveals a novel low-grade molecular signature in estrogen receptor-positive tumors
Primary human breast tumors were obtained from the National Cancer Centre of Singapore (NCC) Tissue Repository, after appropriate approvals from the NCC Repository and Ethics Committees. Profiled samples contained at least 50% tumor content.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2294 | biostudies-arrayexpress
TranscriptomicsYAP mediates crosstalk between the Hippo and PI3K-TOR pathway by suppressing PTEN via miR-29
We aimed to identify microRNAs that are regulated by YAP in human mammary epithelial cells. We utilized deep sequencing technology to identify microRNAs that are induced by YAP overexpression and repressed by YAP knockdown.
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-41124 | biostudies-arrayexpress
TranscriptomicsMolecular Rejuvenation of Gene Expression Pattern of Photoaged and Intrinsically Aged Human Skin by Broadband Light Treatment
Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply deep sequencing of RNA 3' ends ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin ...
ORGANISM(S): Homo sapiens 
2012-07-30 | E-GEOD-39170 | biostudies-arrayexpress
GenomicsGenomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions.
Long intergenic noncoding RNAs (lincRNAs) are key regulators of chromatin state, yet the nature and sites of RNA-chromatin interaction are mostly unknown. Here we introduce Chromatin Isolation by RNA Purification (ChIRP), where tiling oligonucleotides retrieve specific lincRNAs and bound protein and...
ORGANISM(S): Drosophila 
2011-09-29 | E-GEOD-31332 | biostudies-arrayexpress
TranscriptomicsIdentification of Proteins Binding Coding and Non-coding Human RNAs using Protein Microarrays
We describe a refined approach to identify new human RNA-protein interactions. In vitro transcribed labeled RNA is bound to ~9,400 human recombinant proteins spotted on protein microarrays. This approach identified 137 RNA-protein interactions for 10 human coding and non-coding RNAs, including an in...
ORGANISM(S): Homo sapiens 
2012-10-10 | E-GEOD-34794 | biostudies-arrayexpress
TranscriptomicsSuppression of progenitor differentiation requires the long noncoding RNA ANCR
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-58161 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of brain in humans, chimpanzees and macaques, and brain, heart, kidney and liver in orangutans
An experiment was performed to study positive selection on expression regulation in human tissues by comparing expression values in humans to those in chimpanzees, orangutans and rhesus macaques.
ORGANISM(S): Pan troglodytes 
2006-04-18 | E-TABM-84 | biostudies-arrayexpress
TranscriptomicsControl of Somatic Tissue Differentiation by the Long Non-Coding RNA TINCR (HTS)
Several of the thousands of human long non-coding RNAs (lncRNAs) have been functionally characterized; however, potential roles for lncRNAs in somatic tissue differentiation remain poorly understood. Here we show that a 3.7kb lncRNA, terminal differentiation-induced ncRNA (TINCR), controls human epi...
ORGANISM(S): Homo sapiens 
2012-10-10 | E-GEOD-40121 | biostudies-arrayexpress
GenomicsIdentification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells
In this work, we characterized the epigenomic integrity of 17 hiPSC lines derived from six different cell types with varied reprogramming efficiencies. We demonstrate that epigenetic aberrations are a general feature of the hiPSC state and are independent of the somatic cell source. Additionally, we...
ORGANISM(S): Homo sapiens 
2012-08-28 | E-GEOD-40372 | biostudies-arrayexpress
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
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