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MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
TranscriptomicsTDP-43 regulates cancer-associated microRNAs
MicroRNAs (miRNAs) play important roles in a wide range of cellular processes. Aberrant regulation of miRNA genes contributes to human diseases, including cancer. The TAR DNA binding protein 43 (TDP-43), a DNA/RNA binding protein associated with neurodegeneration, is involved in miRNA biogenesis. He...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-85065 | biostudies-arrayexpress
TranscriptomicsSpecific sequence determinants of miR-15/107 microRNA gene group targets
Using anti-Argonaute (anti-AGO) antibody co-immunoprecipitation, followed by microarray analyses and downstream bioinformatics, ‘RIP-Chip’ experiments enable direct analyses of miRNA targets. The analyses support four major findings: (i) RIP-Chip studies correlated with total input mRNA profiling pr...
ORGANISM(S): Homo sapiens 
2012-12-11 | E-GEOD-42823 | biostudies-arrayexpress
TranscriptomicsThe expression profiles of 82 novel and 245 known human imsRNAs
The expression profiling of 245 known and 82 novel imsRNAs (intermediate-size noncoding RNAs, 50-500nt, which were identified from human fetal brain tissue) across different human fetal tissues (brain, heart, liver, lung and spleen at the 24-week gestation stage), different fetal brain gestational s...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-26196 | biostudies-arrayexpress
TranscriptomicsDeep profiling of the novel intermediate-size noncoding RNAs in intraerythrocytic Plasmodium falciparum
Intermediate-size noncoding RNAs (is-ncRNAs) have been shown to play important regulatory roles in the development of several eukaryotic organisms. However, they have not been thoroughly explored in Plasmodium falciparum, which is the most virulent malaria parasite infecting human being. By using Il...
ORGANISM(S): Plasmodium falciparum 
2014-03-30 | E-GEOD-45172 | biostudies-arrayexpress
TranscriptomicsaCGH of metastatic castration resistant prostate cancer (mCRPC)
Copy number profiling of mCRPC
ORGANISM(S): Homo sapiens 
2020-04-28 | E-MTAB-7326 | biostudies-arrayexpress
TranscriptomicsArray-based Comparative Genomic Hybridization of Melanoma Cell Lines
This study explored the role of targeting protein for Xklp2 (TPX2), located with 20q11.2, in melanoma pathogenesis, based on initial findings that it was commonly gained and overexpressed. TPX2 copy number was evaluated in melanoma cell lines compared to control DNA. Thrity-three cell lines were ana...
ORGANISM(S): Homo sapiens 
2012-08-27 | E-GEOD-38946 | biostudies-arrayexpress
TranscriptomicsWnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.
We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond to therapeutic stress by increasing p21 an...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-50004 | biostudies-arrayexpress
ProteomicsMass spectrometry-based proteomics reveals potential roles of NEK9 and MAP2K4 in resistance to PI3K inhibitors in triple negative breast cancer

Filip Mundt, Sandeep Rajput, Shunqiang Li, Kelly Ruggles, Arshag D. Mooradian, Philipp Mertins, Michael A. Gillette, Karsten Krug, et al., Cancer Res. 2018 May 15;78(10):2732-2746. doi: 10.1158/0008-5472.CAN-17-1990.

Activation of phosphoinositide 3-kinase (PI3K) signaling is frequently obs...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-19 | MSV000083050 | MassIVE
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