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ProteomicsManassantin A SILAC-Pulse Proteolysis
Manassantin A is a natural product that has been isolated from the perennial herb Saururus chinensis Baill and the aquatic plant Saururus cernuus. Manassantin A has been shown to possess potent hypoxia inducible factor 1 alpha (HIF-1α) inhibitory activity in a cell-based assay screen of thousands o...
ORGANISM(S): Homo sapiens (Human) 
2016-07-19 | PXD002305 | Pride
Drug mode-of-action In-gel digestion Mda-mb-231 Pulse proteolysis Stable isotope labeling of amino acids in cell culture Manassantin a 
ProteomicsMManassantin A iTRAQ-SPROX Drug Mode-of-Action
Manassantin A is a natural product that has been isolated from the perennial herb Saururus chinensis Baill and the aquatic plant Saururus cernuus. Manassantin A has been shown to possess potent hypoxia inducible factor 1 alpha (HIF-1α) inhibitory activity in a cell-based assay screen of thousands o...
ORGANISM(S): Homo sapiens (Human) 
2016-07-12 | PXD002304 | Pride
Drug mode-of-action Stability of proteins from rates of oxidation (sprox) Mda-mb-231 Protein-ligand binding interactions Manassantin a Itraq 
UnknownThe lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals.
Not available
S-EPMC5743073 | biostudies-literature
UnknownDiscovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.
Not available
S-EPMC5270646 | biostudies-literature
UnknownSynthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.
Not available
S-EPMC4765894 | biostudies-literature
GenomicsManassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity
Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity
PRJNA434512 | ENA
UnknownManassantin B attenuates obesity by inhibiting adipogenesis and lipogenesis in an AMPK dependent manner.
Not available
S-EPMC9813681 | biostudies-literature
UnknownManassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity.
Not available
S-EPMC10070431 | biostudies-literature
TranscriptomicsManassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity
Background: Chaperon-mediated autophagy (CMA) has taken on a new emphasis in cancer biology. However, the roles of CMA in hypoxic tumours are poorly understood. We investigated the anti-tumour effects of the natural product ManA through the activation of CMA in tumour progression under hypoxia. Meth...
ORGANISM(S): Homo sapiens 
2024-01-22 | GSE110768 | GEO
UnknownFalse-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform.
Not available
S-EPMC3880622 | biostudies-literature
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