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TranscriptomicsTranscription profiling of human hemopoietic progenitors and myeloid differentiated cells
Differential gene expression profiling of human hemopoietic progenitors and myeloid differentiated cells Experiment Overall Design: We assessed the gene expression in Lin+CD34+, CD14+, CD16+ and CD16- cells.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3242 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD43+ cells from idiopathic myelofibrosis patients vs normal individuals identifies a set of disease-associated genes and reveals the clinical significance of Wilms tumor gene 1 (WT1)
IM CD34+ vs BM CD34+ cells Experiment Overall Design: Differential gene expression profiling of CD34+ cells purified from the PB of 15 IM patients (3 distinct pools) and from the BM of 15 healthy subjects (3 distinct pools)
ORGANISM(S): Homo sapiens 
2007-11-08 | E-GEOD-3410 | biostudies-arrayexpress
TranscriptomicsChronic myelogenous leukemia hematopoietic stem cells
We show the molecular and functional characterization of a novel population of lineage-negative CD34-negative (Lin- CD34-) hematopoietic stem cells (HSCs) from chronic myelogenous leukemia (CML) patients at diagnosis. Molecular caryotyping and quantitative analysis of BCR/ABL transcript demonstrated...
ORGANISM(S): Homo sapiens 
2010-01-04 | E-GEOD-11675 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human samples to investigate CD34 antigen role in haematopoietic commitment (GEO Super Series)
This SuperSeries is composed of the following subset Series:; GSE8002: CD34 gene silencing; GSE8003: CD34 Overexpression Experiment Overall Design: Refer to individual Series
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-8040 | biostudies-arrayexpress
TranscriptomicssiRNA of human CD34+ cells to investigate the role of CD34 antigen in haematopoietic committment
In order to investigate the role of CD34 antigen in haematopoietic commitment, we silenced the CD34 gene expression in CD34+ stem/progenitor cells using a siRNA approach. Experiment Overall Design: To maximize siRNA transfection efficiency, we utilized the NucleofectorTM technology (Amaxa). CD34+ c...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-8002 | biostudies-arrayexpress
TranscriptomicsInhibition of Jak2 in SET2 cell line with INC424 (two time points and 3 dose levels in triplicate)
SET2 cells were incubated with increasing concentration of INC424/Ruxolitinib for 3-6 h and RNA was purified. Affymetrix Genechip miRNA array 2.0 was used to identify miRNA species showing a differential expression in treated cells compared with control cells. Exponentially growing SET2 cells were c...
ORGANISM(S): Homo sapiens 
2012-02-08 | E-GEOD-33809 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34 cDNA over-expressing human CD34+ cells
In order to investigate the role of CD34 antigen in haematopoietic commitment, we overexpressed the human CD34 cDNA in human CD34+ cells by retroviral gene transfer. Experiment Overall Design: In a set of 10 independent experiments, gene transfer efficiency, assessed by flow cytometry analysis of Î...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-8003 | biostudies-arrayexpress
TranscriptomicsMYB/miR4863p/MAF/ axis in hematopoietic progenitor cell fate decision
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-60301 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD34+ progenitor cells
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb in human hematopoietic lineage commitment, we studied the effects of its silencing during the commitment of human CD34+ Hematopoietic stem/progeni...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-13110 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD14-myeloblasts
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb during the terminal differentiation of hematopoietic precursors, we studied the effects of its silencing in human primary CD14-myeloblasts, which ...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21943 | biostudies-arrayexpress
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