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TranscriptomicsTranscription profiling of human umbilical cord blood derived mast cells IgE sensitized followed by crosslinking receptor at different time points
Human umbilical cord blood derived mast cells IgE sensitized followed by crosslinking receptor at different time points
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1933 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of lactacystin-mediated neuronal death
Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as ParkinsonM-bM-^@M-^Ys disease and AlzheimerM-bM-^@M-^Ys disease. Pharmacological proteasomal inhibitors such as lactacystin can induce apoptosis in cultured mouse co...
ORGANISM(S): Mus musculus 
2012-01-03 | E-GEOD-22465 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of nitric oxide-mediated neuronal death
Nitric oxide (NO) is implicated in the pathogenesis of various neuropathologies characterised by oxidative stress. NO has been reported to be involved in the exacerbation of oxidative stress by various mechanisms, including protein modification, genotoxic damage and elevated production of reactive o...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-22087 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths
Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagon...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-16035 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model.
Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23160 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo Gpx1 -/- transgenic mouse model.
Glutathione peroxidase (Gpx) is a selenium-containing enzyme that catalyses the reduction of a variety of biological peroxides at the expense of reduced glutathione (GSH). Gpx1 is the most abundant isoform and its role has been implicated in neurodegenerative disorders such as ParkinsonM-bM-^@M-^Ys ...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23162 | biostudies-arrayexpress
TranscriptomicsCell cycle regulatory mechanisms in skeletal muscle cells
Genome wide gene expression analysis in G9a knockdown myoblasts Illumina WG-6 v2.0 arrays were hybridized with RNA from scrambled control and siG9a myoblasts to determine the gene expression profile murine skeletal myoblasts. All hybridizations were done in biological duplicates
ORGANISM(S): Mus musculus 
2016-07-21 | E-GEOD-70039 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of oxygen-glucose deprivation (OGD)-mediated neuronal injury
Oxygen-glucose deprivation (OGD) is a cellular phenomenon consistently observed upon occurrence of ischemic stroke which eventually results in neuronal death. Neuronal cell death after ischemia takes place via two distinct processes, necrosis and apoptosis. Apoptosis, programmed cell death, is denot...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-23158 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced neuronal death
AMPA receptors are involved not only in neuronal plasticity but also in excitotoxicity, mediated largely by the influx of Ca2+ (Choi et al., 1988). Their implication has been highlighted in animal models of ischemia and epilepsy. Studies of ischemic rodent models featured that prior to cell death, h...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-22993 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling of kainate-induced neuronal death
It has long been established that in neurological disease models, KA is a potent excitotoxin, mediating acute limbic seizures and long-term morphologic changes in the hippocampus, which are hallmark characteristics seen in temporal lobe epilepsy (i.e. mossy-fiber sprouting, neuronal loss, and reacti...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-22994 | biostudies-arrayexpress
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