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TranscriptomicsTranscriptional profiling of patient-derived xenograft models of myxoid liposarcoma either responsive or resistant to trabectedin treatment.
Transcriptional profiling of patient-derived xenograft models of myxoid liposarcoma with either FUS-CHOP type I, named as ML017, or FUS-CHOP type III, named as ML006. Both ML017 and ML006 are responsive to trabectedin treatment, while model ML017/ET has aquired resistance to the drug. Samples are ei...
ORGANISM(S): Homo sapiens 
2020-01-10 | E-MTAB-8632 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of the MV4-11 cell line treated with trabectidin or azacitidin
In order to study the effects of trabectedin in chronic myelomonocytic leukemia and in juvenile myelomonocytic leukemia, we performed whole genome transcriptional profiling of a model cell line treated under either the reference drug for CMML / JMML (Azacitidine) or trabectedin.
ORGANISM(S): Homo sapiens 
2016-12-14 | E-MTAB-2978 | biostudies-arrayexpress
TranscriptomicsCopy number profiling via ArrayCGH on high grade serous epithelial ovarian cancer samples from multiple biopsies
We performed Array CGH on 25 patients with high grade serous epithelial ovarian cancer (HGS-EOC): each of this had multiple biopsies taken at the moment of the surgery in different anatomical sites, and 18 had also temporal biopsies taken after several cycles of chemotherapy. Blood was used as contr...
ORGANISM(S): Homo sapiens 
2019-12-19 | E-MTAB-6900 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression profiling of a fibrosarcoma GPNMB-induced cell line MCA-1-GPNMB at basal condition and in the form of spheroids
The expression of the soluble protein GPNMB (glycoprotein non-metastatic melanoma protein B) induces an aggressive behavior of tumor cells by promoting proliferation and distant spread. The main molecular feature is the over expression of interleukin Il-33. The gene profile of MCA-1-GPNMB and MCA-1-...
ORGANISM(S): Mus musculus 
2020-07-30 | E-MTAB-8082 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of the MV4-11 cell line treated with trabectidin or azacitidin
In order to study the effects of trabectedin in chronic myelomonocytic leukemia and in juvenile myelomonocytic leukemia, we performed whole genome transcriptional profiling of a model cell line treated under either the reference drug for CMML / JMML (Azacitidine) or trabectedin.
ORGANISM(S): Homo sapiens 
2017-04-30 | E-MTAB-2979 | biostudies-arrayexpress
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