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TranscriptomicsTAL1 regulated miRNAs
miRNA profiling of Jurkat T-ALL cells after knockdown with two control shRNAs and two shRNAs targeting TAL1 to identify miRNAs that are regulated by TAL1 miRNA profiling using Exiqon arrays 48hrs after transduction of Jurkat cells with two control shRNAs (pLKO1-GFP and pLKO1-LUCIFERASE) vs two shRNA...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-46957 | biostudies-arrayexpress
GenomicsAn Oncogenic Super-Enhancer Formed through Somatic Mutation of a Noncoding Intergenic Element
In many cancers, critical oncogenes are driven from large regulatory elements, called super-enhancers, which recruit much of the cellM-bM-^@M-^Ys transcriptional apparatus and are defined by extensive H3K27 acetylation. We found that in T-cell acute lymphoblastic leukemia (T-ALL), somatic heterozyg...
ORGANISM(S): Homo sapiens 
2014-11-13 | E-GEOD-59657 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon tumor vs normal DNA
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the cancer process. Here, we engineered lymphoma-prone mice with chromosomal instability to assess the utility of mouse models in cancer gene discovery and the extent of cross-...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7604 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human GBM tumor vs. normal human DNA induced in mice
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the cancer process. Here, we engineered lymphoma-prone mice with chromosomal instability to assess the utility of mouse models in cancer gene discovery and the extent of cross-...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7602 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Atm-/-,mTerc-/-,p53-/- triple knock out lymphoma vs. normal mouse DNA (GPL2884)
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the cancer process. Here, we engineered lymphoma-prone mice with chromosomal instability to assess the utility of mouse models in cancer gene discovery and the extent of cross-...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7600 | biostudies-arrayexpress
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
UnknownTownes-Brocks syndrome: genotype-phenotype correlations of SALL1 variants in our series and the literature.
Not available
S-EPMC12583617 | biostudies-literature
TranscriptomicsComparative genomic hybridization (CGH) of human melanoma vs. normal human samples
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the cancer process. Here, we engineered lymphoma-prone mice with chromosomal instability to assess the utility of mouse models in cancer gene discovery and the extent of cross-...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7606 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pancreatics tumors vs. normal tissue
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the cancer process. Here, we engineered lymphoma-prone mice with chromosomal instability to assess the utility of mouse models in cancer gene discovery and the extent of cross-...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7599 | biostudies-arrayexpress
UnknownRelationship Between Age and Pathology With Treatment of Pediatric and Adolescent Discoid Lateral Meniscus: A Report From the SCORE Multicenter Database.
Not available
S-EPMC10623608 | biostudies-literature
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