Sort   by:  
 Page size 
TranscriptomicsSingle cell analysis of the Common Lymphoid Progenitor compartment reveals functional and molecular heterogeneity
In order to investigate molecular events involved in the regulation of lymphoid lineage commitment, we crossed lamda5 reporter transgenic mice to mice where the GFP gene is inserted into the Rag1 locus. This allowed us to sub-fractionate common lymphoid progenitors (CLPs) and pre-pro-B cells into la...
ORGANISM(S): Mus musculus 
2009-11-24 | E-GEOD-19142 | biostudies-arrayexpress
TranscriptomicsGlobal changes in the nuclear positioning of chromatin domains and genomic interactions that orchestrate B cell fate
The genome is folded into domains that are located in either transcriptionally inert or permissive compartments. Here we used genome-wide strategies to characterize domains during B cell development. Structured Interaction Matrix Analysis revealed that CTCF occupancy was primarily associated with i...
ORGANISM(S): Mus musculus 
2012-10-09 | E-GEOD-40173 | biostudies-arrayexpress
TranscriptomicsA global network of transcription factors, involving E2A, EBF1 and FOXO1, that orchestrates the B cell fate
It is now established that the transcription factors E2A, EBF1 and FoxoM-BM- 1 play critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1 as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis...
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-21978 | biostudies-arrayexpress
TranscriptomicsExpression profiling of early lymphoid progenitors deficient for Ebf1 and Foxo1
Foxo1 and Ebf1 deficiency leads to a similar disruption of normal B-cell development at the level of the common lymphoid progenitor (CLP). Both mouse strains display the existance of LY6D+ CLPs but a marked/complete lack of proB cells. To investigate similarities of the developmental defects observe...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-41931 | biostudies-arrayexpress
GenomicsBrg1 activates enhancer repertoires to establish B cell identity and modulate cell growth
Early B cell development is orchestrated by the combined activities of the transcriptional regulators E2A, EBF1, Foxo1 and Ikaros. However, how the genome-wide binding patterns of these regulators are modulated during B-lineage development remains to be determined. Here, we found that in lymphoid pr...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-66978 | biostudies-arrayexpress
TranscriptomicsInteractions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
Full title: Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication In order to identify extra cellular signals that promote B lymphocyte development we created a database with approximately 400 receptor ligand...
ORGANISM(S): Mus musculus 
2010-01-05 | E-GEOD-19729 | biostudies-arrayexpress
Sort   by:  
 Page size