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TranscriptomicsSecreted transcription factor controls Mycobacterium tuberculosis virulence
This SuperSeries is composed of the following subset Series: GSE11696: Gene expression profile of M.tuberculosis espR (Rv3849) mutant GSE12379: Gene expression profile of M.tuberculosis espR (Rv3849) mutant complemented with an N-terminal Flag espR gene GSE12380: Gene expression profile of M.tubercu...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-12382 | biostudies-arrayexpress
TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutant
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-07-04 | E-GEOD-11696 | biostudies-arrayexpress
TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutant complemented with an N-terminal Flag espR gene
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-08-08 | E-GEOD-12379 | biostudies-arrayexpress
TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutants containing N- or C-terminal mutations in the espR gene
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-12380 | biostudies-arrayexpress
TranscriptomicsComparative analysis of the gene expression profiles of M.tuberculosis espR (Rv3849) transposon and knockout mutants
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-12381 | biostudies-arrayexpress
TranscriptomicsThe IRF3 dependent response of macrophages to M. tuberculosis infection
Transcriptional profiling of macrophages (wild-type and IRF3-/- ) infected with various M.tuberculosis strains (wild-type and ESX-1 mutant) Comparison of the global gene expression of wild-type BMDM macrophages and IRF3-/- macrophages infected with either wild-type M.tuberculosis or ESX-1 mutant M.t...
ORGANISM(S): Mus musculus 
2012-03-31 | E-GEOD-36686 | biostudies-arrayexpress
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