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MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
TranscriptomicsGene expression profiles of PDX models with acquired resistance to endocrine treatments
Acquired resistance to endocrine therapy occurs with high frequency in patients with luminal breast cancer (LBC). We report here the establishment of four patient-derived xenograft models of LBC with acquired resistance in vivo to tamoxifen and estrogen deprivation. CEL files represent expresison da...
ORGANISM(S): Homo sapiens 
2014-07-09 | E-GEOD-55561 | biostudies-arrayexpress
GenomicsBreast cancer bone metastases
Data Access Committee EGAC00001001548
EGAC00001001548 | EGA
GenomicsBreast cancer bone metastases
Data Access Committee EGAC00001002771
EGAC00001002771 | EGA
GenomicsBreast cancer bone metastases
Data Access Committee EGAC00001002772
EGAC00001002772 | EGA
GenomicsBreast cancer bone metastases
Data Access Committee EGAC00001003035
EGAC00001003035 | EGA
GenomicsBreast cancer bone metastases
Data Access Committee EGAC00001003238
EGAC00001003238 | EGA
GenomicsData access policy for PDTX Breast Cancer data from Bruna et al (2016), Cell.
Data Access Committee EGAC00001000540
EGAC00001000540 | EGA
Genomicsena-DATASET-CRUK-CI-15-09-2016-11:30:35:546-51 - samples
Breast cancer PDTX sequencing data from Bruna et al, Cell 2016 - Exome Sequencing - Shallow Whole Genome Sequencing - RRBS Methylation Sequencing
EGAD00001002685 | EGA
Genomicsena-DATASET-CRUK-CI-22-07-2020-08:24:26:904-1617 - samples
RNA-SEQ for the Caldas Lab breast cancer PDTX collection. This includes both single and paired end runs
EGAD00001006307 | EGA
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