Sort   by:  
 Page size 
TranscriptomicsTherapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma through derepression of DUSP1 phosphatase and inhibition of ERK
We have investigated the role of the Notch pathway in the generation and maintenance of KrasG12V-driven non-small cell lung carcinomas (NSCLCs). We demonstrate by genetic means that γ-secretase and Rbpj activities are both essential in the formation of NSCLCs. Interestingly, pharmacologic treatment ...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-38054 | biostudies-arrayexpress
UnknownNOTCH1 intracellular domain stabilization by MDM2 plays a major role in NSCLC response to platinum
Not available
S-SCDT-10_1038-S44321-025-00354-9 | biostudies-other
TranscriptomicsProgrammed cell senescence during embryonic development
Cellular senescence disables the proliferation of damaged cells and it is relevant for cancer and aging. Here, we show that cellular senescence occurs during mammalian embryonic development. Specifically, we have focused on the mouse regressing mesonephros and the endolymphatic sac of the inner ear....
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-49108 | biostudies-arrayexpress
Sort   by:  
 Page size