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TranscriptomicsRNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
A1AT deficiency is an autosomal not recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant retain polymerised protein in the endoplasmic reticulum of hepatocytes, predisposing them to liver disease. This study primarily aimed to uncover the molecular mechanisms t...
ORGANISM(S): Homo sapiens 
2018-06-26 | E-MTAB-6781 | biostudies-arrayexpress
UnknownLubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation: a double-blind, active-comparator trial.
Not available
S-EPMC4239525 | biostudies-literature
TranscriptomicsProbing the regulatory effects of specific mutations in three major binding domains of the pleiotropic regulator CcpA of Bacillus subtilis
Study the effect of single amino acid point mutations in CcpA at the transcriptome level. Cells were grown in LB with or without 1% glucose and harvested at an OD600 of 0.3 (early exponential phase). Bacillus subtilis strain ccpA::spec carrying pHT304 (empty plasmid), pWH_ccpA_M17R, pWH_ccpA_T62H, o...
ORGANISM(S): Bacillus subtilis 
2015-12-24 | E-GEOD-69575 | biostudies-arrayexpress
UnknownAnther dehiscence is regulated by gibberellic acid in yellow lupine (Lupinus luteus L.).
Not available
S-EPMC8252261 | biostudies-literature
TranscriptomicsRegulation of ykrL (htpX) by Rok and YkrK, a novel type of regulator in Bacillus subtilis
Expression of ykrL of Bacillus subtilis, encoding a close homologue of the Escherichia coli membrane protein quality control protease HtpX, was shown to be upregulated under membrane protein overproduction stress. Using DNA affinity chromatography, two proteins were found to bind to the promoter reg...
ORGANISM(S): Bacillus subtilis 
2012-04-03 | E-GEOD-33456 | biostudies-arrayexpress
ProteomicsSeasonal trade-offs shape metabolomic and proteomic responses to Varroa destructor parasitisation in honey bees
The ectoparasitic mite Varroa destructor is a major driver of honey bee mortality, yet its impact depends on the specific phenotypes of summer and winter worker bees. Here, we apply an LC-MS/MS-based proteomics to dissect how Varroa parasitisation affects the molecular physiology of short-lived summ...
ORGANISM(S): Apis mellifera (Honeybee) 
2026-03-11 | PXD073444 | Pride
UnknownAssessment of the Prescribing Pharmacist's Role in Supporting Access to Prescription-Only Medicines-Metadata Analysis in Poland.
Not available
S-EPMC10743265 | biostudies-literature
ModelsChulian2021 - feedback signalling in B lymphopoeisis
Salvador Chulián, Álvaro Martínez-Rubio, Anna Marciniak-Czochra, Thomas Stiehl, Cristina Blázquez Goñi, Juan Francisco Rodríguez Gutiérrez, Manuel Ramírez Orellana, Ana Castillo Robleda, Víctor M. Pérez-García & María Rosa. Dynamical properties of feedback signalling in B lymphopoiesis: A mathematic...
2024-09-02 | BIOMD0000001056 | BioModels
UnknownAssessment of the Susceptibility of Clinical Gram-Negative and Gram-Positive Bacterial Strains to Fosfomycin and Significance of This Antibiotic in Infection Treatment.
Not available
S-EPMC9786176 | biostudies-literature
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts (MEF) from wild type vs CHOP-/- genotypes treated with tunicamycin reveals CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
Primary mouse embryonic fibroblasts (pass 3 to 4) were treated with tunicamycin (2 micrograms/ml) for specified times - genotypes were WILDTYPE and CHOP-/-. Each time point n=4. C/EBP homologous protein CHOP is activated by ER stress, and CHOP deletion protects against its lethal consequences.
ORGANISM(S): Mus musculus 
2007-12-11 | E-GEOD-2082 | biostudies-arrayexpress
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