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TranscriptomicsProtease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
During chronic liver disease, tissue remodeling leads to dramatic changes and accumulation of matrix components. Matrix metalloproteases and their inhibitors have been involved in the regulation of matrix degradation. However, the role of other proteases remains incompletely defined. We undertook a ...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-24667 | biostudies-arrayexpress
TranscriptomicsAtorvastatin effect on SaOS2 osteosarcoma cells
SaOS2 osteosarcoma cells were cultured with or without atorvastatin (10 µM) for 6, 15 or 24h (2 biological replcates). RNA were isolated and hybridized to RNG microarrays. Background Osteosarcoma is the most common primary tumor of bone. The rapid development of metastatic lesions and resistance to...
ORGANISM(S): Homo sapiens 
2011-02-22 | E-GEOD-24401 | biostudies-arrayexpress
TranscriptomicsMiRNA and lung cancer (INCA project) - 40 miRNAs microarrays
MicroRNA expression pattern in 20 pairs of primary lung cancers and their corresponding non cancerous lung tissues. These specimens were obtained from the Nice Hospital Tumor Bio Bank, France. Dye swap-experiment comparing cancerous tissue versus adjacent normal lung tissue.
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-18692 | biostudies-arrayexpress
TranscriptomicsMiRNA and lung cancer (INCA project) - 26 RNG25k microarrays
Gene expression analysis in 13 pairs of primary lung cancers and their corresponding non cancerous lung tissues. These specimens were obtained from the Nice Hospital Tumor Bio Bank, France. Dye swap-experiment comparing cancerous tissue versus adjacent normal lung tissue.
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-18694 | biostudies-arrayexpress
UnknownNucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments.
Not available
S-EPMC10652021 | biostudies-literature
TranscriptomicsMicroRNA signature of thyroid tumors of uncertain malignancy
Well-differentiated tumours (WDT) of the thyroid gland can be difficult to diagnose. Focal nuclear clearing can be suggestive of a papillary thyroid carcinoma (PTC), while questionable vascular or capsular penetration may raise the possibility of diagnosis of a follicular thyroid carcinoma (FTC). Th...
ORGANISM(S): Homo sapiens 
2011-08-21 | E-GEOD-15740 | biostudies-arrayexpress
TranscriptomicsTranscriptional signature of wounded keratinocytes reveals selective roles for ERK1/2, P38 and PI3K signalling pathways
Covering denuded dermal surface after injury requires migration, proliferation and differentiation of skin keratinocytes. To clarify the major traits controlling these intermingled biological events, we surveyed the genomic modifications occurring during the course of a scratch closure of cultured h...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-6820 | biostudies-arrayexpress
UnknownOne Step Closer to Coatings Applications Utilizing Self-Stratification: Effect of Rheology Modifiers.
Not available
S-EPMC10425952 | biostudies-literature
TranscriptomicsmiRNA reponse to bleomycin instillation
Comparison of C57BL/6 (sensitive) and BALB/c (resistant) mice challenged by intratracheal bleomycin instillation: miRNA expression profiles were established from lungs derived from the two strains, following a 7- or 14-days PBS or bleomycin administration. One color -experiment with 2 strains of mic...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-34812 | biostudies-arrayexpress
UnknownFrailty impact on postoperative complications and early mortality rates in patients undergoing radical cystectomy for bladder cancer: a systematic review.
Not available
S-EPMC7954492 | biostudies-literature
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