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TranscriptomicsscRNA-seq analysis of lung neutrophils from mice, 24 hours after intranasal exposure to vehicle, 100 ng LPS and 10 µg LPS
Mice intranasally exposed to a low dose of LPS (i.e., 100 ng) are prone to develop features of allergic asthma upon subsequent exposure to house dust mites (HDM) allergens, while mice exposed to vehicle or 100 µg LPS do not develop such features. In order to understand the mechanisms that promote al...
ORGANISM(S): Mus musculus 
2019-07-25 | E-MTAB-6902 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of colonic intestinal epithelial cells (IECs) isolated from naive wild-type C57BL/6 mice, DSS-treated wild-type C57BL/6 mice, Il10-/- C57BL/6 mice and Il10-/- C57BL/6 mice with IEC-specific Rabgef1 deletion
The aim of this study is to compare the transcriptomic profile of colonic intestinal epithelial cells (IECs) at steady-state, and in several models of colitis: in naive wild-type C57BL/6 mice, in wild-type C57BL/6 mice treated for 7 days with 3% dextran sodium sulfate (DSS) in drinking water, in Il1...
ORGANISM(S): Mus musculus 
2019-09-30 | E-MTAB-7315 | biostudies-arrayexpress
TranscriptomicsscRNA-seq analysis of cell subpopulations of the bronchoalveolar lavage fluid of healthy dogs
In dogs, a species for which markers of cell populations are often limiting, we sought to evaluate in an unbiased way the heterogeneity of cell subpopulations in the bronchoalveolar lavage fluid of healthy dogs, by single-cell RNA-sequencing.
ORGANISM(S): Canis lupus familiaris 
2020-06-29 | E-MTAB-9265 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis on RNA from lung eosinophil subpopulation from naive or HDM-treated mice using Affymetrix Mouse Gene 2.0 ST
As opposed to their well-characterized contributions to inflammatory processes, tissue eosinophils are now also thought to contribute to immune homeostasis at mucosal sites such as the gut. Yet, whether such steady-state eosinophils exist in the lung is currently unclear. In this project, we identif...
ORGANISM(S): Mus musculus 
2016-06-07 | E-MTAB-4084 | biostudies-arrayexpress
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