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ProteomicsExploring the HeLa Dark Mitochondrial proteome
In the framework of the Human Proteome Project initiative, we aim to improve mapping and characterization of mitochondrial proteome. In this work we implemented an experimental workflow, combining classical biochemical enrichments and mass spectrometry, to pursue a much deeper definition of mitochon...
ORGANISM(S): Homo sapiens (Human) 
2020-02-27 | PXD014201 | Pride
Personalised medicine Human mitochondria Dark proteins 
ProteomicsExploring the HeLa Dark Mitochondrial proteome
In the framework of the Human Proteome Project initiative, we aim to improve mapping and characterization of mitochondrial proteome. In this work we implemented an experimental workflow, combining classical biochemical enrichments and mass spectrometry, to pursue a much deeper definition of mitochon...
ORGANISM(S): Homo sapiens (Human) 
2020-02-27 | PXD014200 | Pride
Personalised medicine Subproteome Mass spectrometry Mitochondria Drug targets Dark proteome 
ProteomicsExploring the impact of PARK2 mutations on the total and mitochondrial proteome of human skin fibroblasts
Mutations in PARK2 gene are the most frequent cause of familial forms of Parkinson’s disease (PD). This gene encodes Parkin, an E3 ubiquitin ligase involved in several cellular mechanisms, such as the mitophagic process. Mutations in this gene, which cause the loss of function of Parkin, are respons...
ORGANISM(S): Homo sapiens (Human) 
2020-05-11 | PXD015880 | Pride
Parkinson’s disease Shotgun proteomics Mass spectrometry Human skin fibroblast Park2 mutation Mitochondria Immunoprecipitation 
ProteomicsSequential Fractionation Strategy Identifies Nine Missing Proteins in The Mitochondrial Proteome of Commonly Used Cell Lines
Identification of mitochondrial proteins with a bottom up approach after organelle enrichment and 1D PAGE separation for 5 different cell lines. The bands were cut and the proteins reduced, alkylated and digested with trypsin according to a conventional protocol. Acquisition were performed on the Or...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-05-28 | MSV000082409 | MassIVE
UnknownRivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.
Not available
S-EPMC6662613 | biostudies-literature
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