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MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
UnknownComing in Warm: Qualitative Study and Concept Map to Cultivate Patient-centered Empathy in Emergency Care.
Not available
S-EPMC6457357 | biostudies-literature
UnknownEmergency Department Provider Perspectives on Benzodiazepine-Opioid Coprescribing: A Qualitative Study.
Not available
S-EPMC5764790 | biostudies-literature
ProteomicsProteomic analyses of urinary exosomes identify heparanase, cathepsin C, 2-macroglobulin and sarcoplasmic endoplasmic Ca2+ ATPase-3 (SERCA3) as potential biomarkers for early diagnosis of sickle nephropathy
Sickle cell disease-induced nephropathy (SCN) is a leading cause of morbidity and mortality in sickle cell disease (SCD). Early intervention is crucial for mitigating its effects. However, current diagnostic methods rely on non-specific tests and may not detect SCN until renal damage has become irre...
ORGANISM(S): Mus Musculus (mouse) 
2024-02-07 | PXD043401 | JPOST Repository
UnknownPharmacometabolomics identifies candidate predictor metabolites of an L-carnitine treatment mortality benefit in septic shock.
Not available
S-EPMC8604225 | biostudies-literature
UnknownSuppressing quantum errors by scaling a surface code logical qubit.
Not available
S-EPMC9946823 | biostudies-literature
TranscriptomicsExpression profile of melanoma cells following p300 HAT inhibition
Epigenetic events, including covalent post-translational modification of histones, have frequently been demonstrated to play critical roles in tumor development and progression. The transcriptional coactivator, p300/CBP, possesses both histone acetyltransferase (HAT) activity as well as scaffolding ...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-45981 | biostudies-arrayexpress
TranscriptomicsHistone deacetylase inhibition replicates aspects of the adaptive response to exercise and improves muscle metabolism and cardiac function in obesity.
Drugs used to treat obesity and type 2 diabetes have limited efficacy in directly normalising muscle metabolism. The discovery of molecules mediating exercise adaptations, and drugs that modulate their activity, is a potential strategy to address this therapeutic gap. Here we show that genetic impai...
ORGANISM(S): Mus musculus 
2015-01-28 | E-GEOD-54642 | biostudies-arrayexpress
UnknownCCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study.
Not available
S-EPMC10107112 | biostudies-literature
UnknownWhy START? Reflections that led to the conduct of this large long-term strategic HIV trial.
Not available
S-EPMC4347998 | biostudies-literature
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