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MicroRNAs mediate rapamycin resistance in a myogenic tumor cell line

The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation. Inhibitors of mTOR are being evaluated as anti-tumor agents. Given the emerging role of microRNAs (miRNAs) in tumorgenesis we hypothesized that miRNAs could play important roles in the response of tumors to mTOR i...

ORGANISM(S): Mus musculus

2013-02-08 | E-GEOD-19916 | biostudies-arrayexpress

Gene expression data from rapamycin resistant and sensitive cell lines

ORGANISM(S): Mus musculus

2013-02-08 | E-GEOD-19885 | biostudies-arrayexpress

Cryo-electron microscopy of the liposome-embedded type 1 ryanodine receptor

Not available

EMPIAR-10793 | biostudies-other

Genome wide profiling of MBD2 binding

We show that in vivo MBD2 is mainly recruited to CpG island promoters that are highly methylated. We also report that MBD2 binds to a subset of CpG island promoters that are characterized by the presence of active histone marks and RNA polymerase II (Pol2). At such sites, MBD2 binds downstream of th...

ORGANISM(S): Homo sapiens

2014-07-03 | E-GEOD-54693 | biostudies-arrayexpress

A drug and ATP binding site in type 1 ryanodine receptor

Not available

EMPIAR-10997 | biostudies-other

Challenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives.

Not available

S-EPMC6909648 | biostudies-literature

Impact of postoperative acute kidney injury in patients undergoing major gastrointestinal surgery on 1-year survival and renal outcomes: a national multicentre cohort study.

Not available

S-EPMC8759520 | biostudies-literature

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.