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MetabolomicsSingle-cell and bulk level metabolomic study of the glycolysis inhibition by 2-deoxy-D-glucose in Saccharomyces cerevisiae
Single-cell level measurements are necessary to characterize the intrinsic biological variability in a population of cells. In a study of the metabolic response of a clonal Saccharomyces cerevisiae population challenged by the glycolytic inhibitor 2-deoxy-D-glucose (2-DG), this variability is shown ...
2013-05-22 | MTBLS29 | MetaboLights
TranscriptomicsMassive redeployment of PRC1 proteins suppresses tumor formation during Drosophila development
Polycomb group proteins form two main complexes, PRC2 and PRC1, which generally coregulate their target genes. Here, we show that PRC1 components act as neoplastic tumor suppressors independently of PRC2 function. By mapping the distribution of PRC1 components and the histone H3K27me3 mark, we ident...
ORGANISM(S): Drosophila melanogaster 
2016-07-18 | E-GEOD-74080 | biostudies-arrayexpress
TranscriptomicsPARP1- and CTCF-mediated interactions between active and repressed chromatin at the lamina promote oscillating transcription
Transcriptionally active and inactive chromatin domains tend to segregate into separate sub-nuclear compartments to maintain stable expression patterns. However, we have uncovered here an inter-chromosomal network connecting active loci enriched in circadian genes to repressed lamina-associated doma...
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-26880 | biostudies-arrayexpress
UnknownCERT1 mutations perturb human development by disrupting sphingolipid homeostasis.
Not available
S-EPMC10178846 | biostudies-literature
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