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ProteomicsLate endosomes,lysosomes isolated from frozen autopsy human brains age matched controls, Niemann Pick type C and juvenile CLN3 disease.
An immunopurification strategy was used to isolate intact LE, Lys from frozen human autopsy brain samples. LE, Lys isolated from BA9 samples of JNCL patients were compared with age matched unaffected controls and Niemann Pick Type C (NPC) disease patients. The protein content of LE, Lys was analyzed...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-07 | MSV000091428 | MassIVE
TranscriptomicsIncrease in membrane cholesterol of neurons in culture recapitulates AlzheimerM-bM-^@M-^Ys disease early phenotypes.
Levels of membrane-associated cholesterol were shown to be increased in the brain of individuals with sporadic AlzheimerM-bM-^@M-^Ys disease (AD) and correlated with the severity of the disease. We previously found that heavy membrane cholesterol burden promotes amyloid precursor protein (APP) endoc...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-GEOD-46221 | biostudies-arrayexpress
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