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TranscriptomicsAn Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases
The epidermal growth factor receptor (EGFR) is overexpressed in approximately 90% of head and neck squamous cell carcinomas (HNSCC), and molecularly targeted therapy against the EGFR with the monoclonal antibody cetuximab modestly increases overall survival in head and neck cancer patients. We hypot...
ORGANISM(S): Homo sapiens 
2016-03-22 | E-GEOD-67500 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of follicular lymphoma cells
The hallmark of follicular lymphoma (FL) is the t(14;18) chromosomal translocation. However, constitutive expression of anti-apoptotic Bcl-2 alone is insufficient for lymphomagenesis and subsequent molecular hits are required. We explored the role of microRNA (miRNA or miR) in the biology of FL by...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-28090 | biostudies-arrayexpress
TranscriptomicsGermline Aberrations of PAX5 Cause Susceptibility to pre-B cell Acute Lymphoblastic Leukemia
A novel heterozygous germline variant, c.547G>A (p.Gly183Ser), in the paired box protein encoding gene, PAX5, was found to segregate with disease in two unrelated kindreds with autosomal dominant pre-B cell acute lymphoblastic leukemia (ALL). Leukemic cells from both families exhibited 9p deletion, ...
ORGANISM(S): Mus musculus 
2014-04-06 | E-GEOD-45834 | biostudies-arrayexpress
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