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TranscriptomicsColonic gene expression data of TIMP1 knock out colitis mice
Increased levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) have been detected in fibrotic strictures in Crohn’s disease. In a murine model of chronic inflammation, fibrosis was associated with an increase in TIMP-1 and inhibition of matrix metalloproteinase (MMP)-mediated degradation. We...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-73424 | biostudies-arrayexpress
TranscriptomicsDNA damage responsive microRNAs misexpressed in human cancer regulate chemotherapy sensitivity (lung cancer cell lines)
The DNA damage response (DDR) is a cellular process that protects the genetic information against DNA damage and inhibits malignant transformation. Tumor cells are characterized by an aberrant DDR, which is exploited by genotoxic chemotherapy. However, cancer cells are able to develop drug resistan...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-47524 | biostudies-arrayexpress
GenomicsChIP-seq for RUNX1 and ETV6-RUNX1 in an induced pluripotent stem cell model of ETV6-RUNX1 pre-leukaemia
ETV6-RUNX1 is a first-hit mutation in childhood B cell precursor acute lymphoblastic leukaemia. ETV6-RUNX1 is a fusion protein which inherits the DNA-binding runt domain from RUNX1. Here we performed chromatin precipitation for native RUNX1 and ETV6-RUNX1 using RUNX1 antibodies and specifically for ...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12208 | biostudies-arrayexpress
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